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In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase

หน่วยงาน Nanyang Technological University, Singapore

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ชื่อเรื่อง : In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase
นักวิจัย : Lee, Yoke-Peng , Wong, Chi-Hang , Chan, Kheng-Sze , Lai, Soak Kuan , Koh, Cheng Gee , Li, Hoi-Yeung
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Lee, Y.-P., Wong, C.-H., Chan, K.-S., Lai, S.-K., Koh, C.-G., & Li, H.-Y. (2012). In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase. PLoS ONE, 7(9). , 1932-6203 , http://hdl.handle.net/10220/9210 , http://dx.doi.org/10.1371/journal.pone.0045836
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : PLoS ONE
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Under the fluctuating circumstances provided by the innate dynamics of microtubules and opposing tensions resulted from microtubule-associated motors, it is vital to ensure stable kinetochore-microtubule attachments for accurate segregation. However, a comprehensive understanding of how this regulation is mechanistically achieved remains elusive. Using our newly designed live cell FRET time-lapse imaging, we found that post-metaphase RanGTP is crucial in the maintenance of stable kinetochore-microtubule attachments by regulating Aurora B kinase via the NES-bearing Mst1. More importantly, our study demonstrates that by ensuring stable alignment of metaphase chromosomes prior to segregation, RanGTP is indispensible in governing the genomic integrity and the fidelity of cell cycle progression. Our findings suggest an additional role of RanGTP beyond its known function in mitotic spindle assembly during the prometaphase-metaphase transition.

บรรณานุกรม :
Lee, Yoke-Peng , Wong, Chi-Hang , Chan, Kheng-Sze , Lai, Soak Kuan , Koh, Cheng Gee , Li, Hoi-Yeung . (2555). In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Yoke-Peng , Wong, Chi-Hang , Chan, Kheng-Sze , Lai, Soak Kuan , Koh, Cheng Gee , Li, Hoi-Yeung . 2555. "In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Yoke-Peng , Wong, Chi-Hang , Chan, Kheng-Sze , Lai, Soak Kuan , Koh, Cheng Gee , Li, Hoi-Yeung . "In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Lee, Yoke-Peng , Wong, Chi-Hang , Chan, Kheng-Sze , Lai, Soak Kuan , Koh, Cheng Gee , Li, Hoi-Yeung . In vivo FRET imaging revealed a regulatory role of RanGTP in kinetochore-microtubule attachments via Aurora B kinase. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.