ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Binding of translationally controlled tumour protein to the N-terminal domain of HDM2 is inhibited by Nutlin-3.

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Binding of translationally controlled tumour protein to the N-terminal domain of HDM2 is inhibited by Nutlin-3.
นักวิจัย : Funston, Garth. , Goh, Walter. , Wei, Siau Jia. , Tng, Quah Soo. , Brown, Christopher J. , Tong, Loh Jiah. , Verma, Chandra Shekhar. , Lane, David P. , Ghadessy, Farid.
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Funston, G., Goh, W., Wei, S. J., Tng, Q. S., Brown, C. J., Tong, L. J., et al. (2012). Binding of translationally controlled tumour protein to the N-terminal domain of HDM2 is inhibited by Nutlin-3. PLoS ONE, 7(8). , 1932-6203 , http://hdl.handle.net/10220/9204 , http://dx.doi.org/10.1371/journal.pone.0042642
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : PLoS ONE
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Translationally Controlled Tumour Protein (TCTP), a highly conserved protein present in all eukaryotic organisms, has a number of intracellular and extracellular functions including an anti-apoptotic role. TCTP was recently shown to interact with both p53 and HDM2, inhibiting auto-ubiquitination of the latter and thereby promoting p53 degradation. In this study, we further investigated the interaction between TCTP and HDM2, mapping the reciprocal binding sites of TCTP and HDM2. TCTP primarily interacts with the N-terminal, p53-binding region of HDM2 through its highly basic domain 2. Furthermore, we discovered that Nutlin-3, a small molecule known to promote apoptosis and cell cycle arrest by blocking binding between HDM2 and p53, has a similar inhibitory effect on the interaction of HDM2 and TCTP. This result may provide an additional explanation of how Nutlin-derived compounds currently in clinical trials function to promote apoptosis in cancer cells.

บรรณานุกรม :
Funston, Garth. , Goh, Walter. , Wei, Siau Jia. , Tng, Quah Soo. , Brown, Christopher J. , Tong, Loh Jiah. , Verma, Chandra Shekhar. , Lane, David P. , Ghadessy, Farid. . (2555). Binding of translationally controlled tumour protein to the N-terminal domain of HDM2 is inhibited by Nutlin-3..
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Funston, Garth. , Goh, Walter. , Wei, Siau Jia. , Tng, Quah Soo. , Brown, Christopher J. , Tong, Loh Jiah. , Verma, Chandra Shekhar. , Lane, David P. , Ghadessy, Farid. . 2555. "Binding of translationally controlled tumour protein to the N-terminal domain of HDM2 is inhibited by Nutlin-3.".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Funston, Garth. , Goh, Walter. , Wei, Siau Jia. , Tng, Quah Soo. , Brown, Christopher J. , Tong, Loh Jiah. , Verma, Chandra Shekhar. , Lane, David P. , Ghadessy, Farid. . "Binding of translationally controlled tumour protein to the N-terminal domain of HDM2 is inhibited by Nutlin-3.."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Funston, Garth. , Goh, Walter. , Wei, Siau Jia. , Tng, Quah Soo. , Brown, Christopher J. , Tong, Loh Jiah. , Verma, Chandra Shekhar. , Lane, David P. , Ghadessy, Farid. . Binding of translationally controlled tumour protein to the N-terminal domain of HDM2 is inhibited by Nutlin-3.. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.