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Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD)

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD)
นักวิจัย : Kang, Cong Bao , Ye, Hong , Vivekanandan, Subramanian , Simon, Bernd , Sattler, Michael , Yoon, Ho Sup
คำค้น : DRNTU::Science::Biological sciences::Molecular biology.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2549
อ้างอิง : Kang, C. B., Ye, H., Vivekanandan, S., Simon, B., Sattler, M., & Yoon, H. S. (2006). Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD). Journal of Biomolecular NMR, 36(S1), 37. , http://hdl.handle.net/10220/8826 , http://dx.doi.org/10.1007/s10858-006-9001-5
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of biomolecular NMR
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

FK-506 binding protein 38 (FKBP38) interacts with Bcl-2/Bcl-Xl and helps them localize at the mitochondrial membrane (Shirane and Nakayama, 2003). The down-regulation of FKBP38 was shown to influence on the stability of Bcl-2 and consequently induce apoptotic cell death (Kang et al., 2005). FKBP38 is a unique protein among the FKBP family members. Unlike other members in the FKBP family, FKBP38 appears to have no FK-506 binding activity (Shirane and Nakayama, 2003). Thus, to understand the function of FKBP38 at molecular level, as the first step, we performed a NMR study on FKBP38, and here we report the NMR resonance assignments of the N-terminal domain of FKBP38, which includes the FK-506 binding domain and the flanking N-terminal residues. Nearly all of the backbone 1H, 13C, and 15N resonances were assigned ( 99%). Assignments of the side chain atoms beyond Cβ atoms are about 80% complete. The assignments have been deposited with BMRB accession number 6923.

บรรณานุกรม :
Kang, Cong Bao , Ye, Hong , Vivekanandan, Subramanian , Simon, Bernd , Sattler, Michael , Yoon, Ho Sup . (2549). Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD).
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Kang, Cong Bao , Ye, Hong , Vivekanandan, Subramanian , Simon, Bernd , Sattler, Michael , Yoon, Ho Sup . 2549. "Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD)".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Kang, Cong Bao , Ye, Hong , Vivekanandan, Subramanian , Simon, Bernd , Sattler, Michael , Yoon, Ho Sup . "Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD)."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2549. Print.
Kang, Cong Bao , Ye, Hong , Vivekanandan, Subramanian , Simon, Bernd , Sattler, Michael , Yoon, Ho Sup . Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD). กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2549.