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Molecular and structural characterization of the domain 2 of Hepatitis C virus non-structural protein 5A

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Molecular and structural characterization of the domain 2 of Hepatitis C virus non-structural protein 5A
นักวิจัย : Liang, Yu , Kang, Cong Bao , Yoon, Ho Sup
คำค้น : DRNTU::Science::Biological sciences::Microbiology.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2549
อ้างอิง : Liang, Y., Kang, C. B., & Yoon, H. S. (2006). Molecular and structural characterization of the domain 2 of Hepatitis C virus non-structural protein 5A. Molecules and Cells, 22(1), 13-20. , http://hdl.handle.net/10220/8823 , http://www.molcells.org/home/journal/
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Molecules and cells
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Hepatitis C virus (HCV) non-structural protein 5A protein (NS5A), which consists of three functional domains, is involved in regulating viral replication, interferon resistance, and apoptosis. Recently, the three-dimensional structure of the domain 1 was determined. However, currently the molecular basis for the domains 2 and 3 of HCV NS5A is yet to be defined. Toward this end, we expressed, purified the domain 2 of the NS5A (NS5A-D2), and then performed biochemical and structural studies. The purified domain 2 was active and was able to bind NS5B and PKR, biological partners of NS5A. The results from gel filtration, CD analysis, 1D 1H NMR and 2D 1H-15N heteronuclear single quantum correlation (HSQC) spectroscopy indicate that the domain 2 of NS5A appears to be flexible and disordered.

บรรณานุกรม :
Liang, Yu , Kang, Cong Bao , Yoon, Ho Sup . (2549). Molecular and structural characterization of the domain 2 of Hepatitis C virus non-structural protein 5A.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Liang, Yu , Kang, Cong Bao , Yoon, Ho Sup . 2549. "Molecular and structural characterization of the domain 2 of Hepatitis C virus non-structural protein 5A".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Liang, Yu , Kang, Cong Bao , Yoon, Ho Sup . "Molecular and structural characterization of the domain 2 of Hepatitis C virus non-structural protein 5A."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2549. Print.
Liang, Yu , Kang, Cong Bao , Yoon, Ho Sup . Molecular and structural characterization of the domain 2 of Hepatitis C virus non-structural protein 5A. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2549.