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CMOS high density electrical impedance biosensor array for tumor cell detection

หน่วยงาน Nanyang Technological University, Singapore

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ชื่อเรื่อง : CMOS high density electrical impedance biosensor array for tumor cell detection
นักวิจัย : Chen, Yu , Wong, Chee Chung , Pui, Tze Sian , Nadipalli, Revanth , Weerasekera, Roshan , Chandran, Jegatha , Yu, Hao , Rahman, Abdur Rub Abdur
คำค้น : DRNTU::Engineering::Electrical and electronic engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Chen, Y., Wong, C. C., Pui, T. S., Nadipalli, R., Weerasekera, R., Chandran, J., et al. (2012). CMOS high density electrical impedance biosensor array for tumor cell detection. Sensors and actuators B : chemical, 173, 903-907. , 09254005 , http://hdl.handle.net/10220/8797 , http://dx.doi.org/10.1016/j.snb.2012.07.024
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Sensors and actuators B : chemical
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

We present a high-throughput label-free electrical-impedance spectroscopy (EIS) platform composed of a 96 × 96 microelectrode array for counting and analysis of breast tumor cells (MCF-7). These Auelectrodes are densely packed within a 3.5 mm × 3.5 mm interrogation region. Each Au-electrode has an edge-length of 25 μm designed to detect single tumor cell by electrical impedance spectroscopy. The detected signal is read out via an integrated circuit (IC) of addressable electrode-selection-switch array manufactured with 0.18μm CMOS technology. The independently addressable microelectrode array is integrated onto a printed circuit board (PCB) containing associated circuitry for electrode switching and readout. MCF-7 cells were dispensed onto the chip surface and EIS measurements were recorded before and after the cell dispensation. On an average 20% increase in impedance was found associated with cell occupancy on the electrode surface. A positive correlation was observed between cell detection with optical microscopy and with electrical scanning.

บรรณานุกรม :
Chen, Yu , Wong, Chee Chung , Pui, Tze Sian , Nadipalli, Revanth , Weerasekera, Roshan , Chandran, Jegatha , Yu, Hao , Rahman, Abdur Rub Abdur . (2555). CMOS high density electrical impedance biosensor array for tumor cell detection.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chen, Yu , Wong, Chee Chung , Pui, Tze Sian , Nadipalli, Revanth , Weerasekera, Roshan , Chandran, Jegatha , Yu, Hao , Rahman, Abdur Rub Abdur . 2555. "CMOS high density electrical impedance biosensor array for tumor cell detection".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chen, Yu , Wong, Chee Chung , Pui, Tze Sian , Nadipalli, Revanth , Weerasekera, Roshan , Chandran, Jegatha , Yu, Hao , Rahman, Abdur Rub Abdur . "CMOS high density electrical impedance biosensor array for tumor cell detection."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Chen, Yu , Wong, Chee Chung , Pui, Tze Sian , Nadipalli, Revanth , Weerasekera, Roshan , Chandran, Jegatha , Yu, Hao , Rahman, Abdur Rub Abdur . CMOS high density electrical impedance biosensor array for tumor cell detection. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.