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Emerging roles of angiopoietin-like 4 in human cancer

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Emerging roles of angiopoietin-like 4 in human cancer
นักวิจัย : Tan, Ming Jie , Teo, Ziqiang , Sng, Ming Keat , Zhu, Pengcheng , Tan, Nguan Soon
คำค้น : DRNTU::Science::Biological sciences::Molecular biology
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Tan, M. J., Teo, Z., Sng, M. K., Zhu, P., & Tan, N. S. (2012). Emerging Roles of Angiopoietin-like 4 in Human Cancer. Molecular Cancer Research, 10(6), 677-688. , 1557-3125(electronic) , http://hdl.handle.net/10220/8287 , http://dx.doi.org/10.1158/1541-7786.MCR-11-0519 , 165705
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Molecular cancer research
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Angiopoietin-like 4 (ANGPTL4) is best known for its role as an adipokine involved in the regulation of lipid and glucose metabolism. The characterization of ANGPTL4 as an adipokine is largely due to our limited understanding of the interaction partners of ANGPTL4 and how ANGPTL4 initiates intracellular signaling. Recent findings have revealed a critical role for ANGPTL4 in cancer growth and progression, anoikis resistance, altered redox regulation, angiogenesis, and metastasis. Emerging evidence suggests that ANGPTL4 function may be drastically altered depending on the proteolytic processing and posttranslational modifications of ANGPTL4, which may clarify several conflicting roles of ANGPTL4 in different cancers. Although the N-terminal coiled-coil region of ANGPTL4 has been largely responsible for the endocrine regulatory role in lipid metabolism, insulin sensitivity, and glucose homeostasis, it has now emerged that the COOH-terminal fibrinogen-like domain of ANGPTL4 may be a key regulator in the multifaceted signaling during cancer development. New insights into the mechanistic action of this functional domain have opened a new chapter into the possible clinical application of ANGPTL4 as a promising candidate for clinical intervention in the fight against cancer. This review summarizes our current understanding of ANGPTL4 in cancer and highlights areas that warrant further investigation. A better understanding of the underlying cellular and molecular mechanisms of ANGPTL4 will reveal novel insights into other aspects of tumorigenesis and the potential therapeutic value of ANGPTL4.

บรรณานุกรม :
Tan, Ming Jie , Teo, Ziqiang , Sng, Ming Keat , Zhu, Pengcheng , Tan, Nguan Soon . (2555). Emerging roles of angiopoietin-like 4 in human cancer.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tan, Ming Jie , Teo, Ziqiang , Sng, Ming Keat , Zhu, Pengcheng , Tan, Nguan Soon . 2555. "Emerging roles of angiopoietin-like 4 in human cancer".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tan, Ming Jie , Teo, Ziqiang , Sng, Ming Keat , Zhu, Pengcheng , Tan, Nguan Soon . "Emerging roles of angiopoietin-like 4 in human cancer."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Tan, Ming Jie , Teo, Ziqiang , Sng, Ming Keat , Zhu, Pengcheng , Tan, Nguan Soon . Emerging roles of angiopoietin-like 4 in human cancer. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.