| ชื่อเรื่อง | : | Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors |
| นักวิจัย | : | Zhu, Pengcheng , Tan, Ming Jie , Huang, Royston-Luke , Tan, Chek Kun , Chong, Han Chung , Pal, Mintu , Lam, Ivan Chee Ren , Boukamp, Petra , Pan, Jiun Yit , Tan, Suat Hoon , Kersten, Sander , Li, Hoi-Yeung , Ding, Jeak Ling , Tan, Nguan Soon |
| คำค้น | : | DRNTU::Science::Biological sciences::Cytology. |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2554 |
| อ้างอิง | : | Zhu, P., Tan, M. J., Huang, R. L., Tan, C. K., Chong, H. C., Pal, M., et al. (2011). Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2(-): H2O2 Ratio and Confers Anoikis Resistance to Tumors. Cancer cell, 19(3), 401-415. , http://hdl.handle.net/10220/8177 , http://dx.doi.org/10.1016/j.ccr.2011.01.018 , 164662 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Cancer cell |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Cancer is a leading cause of death worldwide. Tumor cells exploit various signaling pathways to promote their growth and metastasis. To our knowledge, the role of angiopoietin-like 4 protein (ANGPTL4) in cancer remains undefined. Here, we found that elevated ANGPTL4 expression is widespread in tumors, and its suppression impairs tumor growth associated with enhanced apoptosis. Tumor-derived ANGPTL4 interacts with integrins to stimulate NADPH oxidase-dependent production of O2(-). A high ratio of O2:(-)H2O2 oxidizes/activates Src, triggering the PI3K/PKBα and ERK prosurvival pathways to confer anoikis resistance, thus promoting tumor growth. ANGPTL4 deficiency results in diminished O2(-) production and a reduced O2:(-)H2O2 ratio, creating a cellular environment conducive to apoptosis. ANGPTL4 is an important redox player in cancer and a potential therapeutic target. |
| บรรณานุกรม | : |
Zhu, Pengcheng , Tan, Ming Jie , Huang, Royston-Luke , Tan, Chek Kun , Chong, Han Chung , Pal, Mintu , Lam, Ivan Chee Ren , Boukamp, Petra , Pan, Jiun Yit , Tan, Suat Hoon , Kersten, Sander , Li, Hoi-Yeung , Ding, Jeak Ling , Tan, Nguan Soon . (2554). Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Zhu, Pengcheng , Tan, Ming Jie , Huang, Royston-Luke , Tan, Chek Kun , Chong, Han Chung , Pal, Mintu , Lam, Ivan Chee Ren , Boukamp, Petra , Pan, Jiun Yit , Tan, Suat Hoon , Kersten, Sander , Li, Hoi-Yeung , Ding, Jeak Ling , Tan, Nguan Soon . 2554. "Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Zhu, Pengcheng , Tan, Ming Jie , Huang, Royston-Luke , Tan, Chek Kun , Chong, Han Chung , Pal, Mintu , Lam, Ivan Chee Ren , Boukamp, Petra , Pan, Jiun Yit , Tan, Suat Hoon , Kersten, Sander , Li, Hoi-Yeung , Ding, Jeak Ling , Tan, Nguan Soon . "Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2554. Print. Zhu, Pengcheng , Tan, Ming Jie , Huang, Royston-Luke , Tan, Chek Kun , Chong, Han Chung , Pal, Mintu , Lam, Ivan Chee Ren , Boukamp, Petra , Pan, Jiun Yit , Tan, Suat Hoon , Kersten, Sander , Li, Hoi-Yeung , Ding, Jeak Ling , Tan, Nguan Soon . Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2554.
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