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Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors

หน่วยงาน Nanyang Technological University, Singapore

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ชื่อเรื่อง : Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors
นักวิจัย : Zhu, Pengcheng , Tan, Ming Jie , Huang, Royston-Luke , Tan, Chek Kun , Chong, Han Chung , Pal, Mintu , Lam, Ivan Chee Ren , Boukamp, Petra , Pan, Jiun Yit , Tan, Suat Hoon , Kersten, Sander , Li, Hoi-Yeung , Ding, Jeak Ling , Tan, Nguan Soon
คำค้น : DRNTU::Science::Biological sciences::Cytology.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2554
อ้างอิง : Zhu, P., Tan, M. J., Huang, R. L., Tan, C. K., Chong, H. C., Pal, M., et al. (2011). Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2(-): H2O2 Ratio and Confers Anoikis Resistance to Tumors. Cancer cell, 19(3), 401-415. , http://hdl.handle.net/10220/8177 , http://dx.doi.org/10.1016/j.ccr.2011.01.018 , 164662
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Cancer cell
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Cancer is a leading cause of death worldwide. Tumor cells exploit various signaling pathways to promote their growth and metastasis. To our knowledge, the role of angiopoietin-like 4 protein (ANGPTL4) in cancer remains undefined. Here, we found that elevated ANGPTL4 expression is widespread in tumors, and its suppression impairs tumor growth associated with enhanced apoptosis. Tumor-derived ANGPTL4 interacts with integrins to stimulate NADPH oxidase-dependent production of O2(-). A high ratio of O2:(-)H2O2 oxidizes/activates Src, triggering the PI3K/PKBα and ERK prosurvival pathways to confer anoikis resistance, thus promoting tumor growth. ANGPTL4 deficiency results in diminished O2(-) production and a reduced O2:(-)H2O2 ratio, creating a cellular environment conducive to apoptosis. ANGPTL4 is an important redox player in cancer and a potential therapeutic target.

บรรณานุกรม :
Zhu, Pengcheng , Tan, Ming Jie , Huang, Royston-Luke , Tan, Chek Kun , Chong, Han Chung , Pal, Mintu , Lam, Ivan Chee Ren , Boukamp, Petra , Pan, Jiun Yit , Tan, Suat Hoon , Kersten, Sander , Li, Hoi-Yeung , Ding, Jeak Ling , Tan, Nguan Soon . (2554). Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhu, Pengcheng , Tan, Ming Jie , Huang, Royston-Luke , Tan, Chek Kun , Chong, Han Chung , Pal, Mintu , Lam, Ivan Chee Ren , Boukamp, Petra , Pan, Jiun Yit , Tan, Suat Hoon , Kersten, Sander , Li, Hoi-Yeung , Ding, Jeak Ling , Tan, Nguan Soon . 2554. "Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhu, Pengcheng , Tan, Ming Jie , Huang, Royston-Luke , Tan, Chek Kun , Chong, Han Chung , Pal, Mintu , Lam, Ivan Chee Ren , Boukamp, Petra , Pan, Jiun Yit , Tan, Suat Hoon , Kersten, Sander , Li, Hoi-Yeung , Ding, Jeak Ling , Tan, Nguan Soon . "Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2554. Print.
Zhu, Pengcheng , Tan, Ming Jie , Huang, Royston-Luke , Tan, Chek Kun , Chong, Han Chung , Pal, Mintu , Lam, Ivan Chee Ren , Boukamp, Petra , Pan, Jiun Yit , Tan, Suat Hoon , Kersten, Sander , Li, Hoi-Yeung , Ding, Jeak Ling , Tan, Nguan Soon . Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-) : H2O2 ratio and confers anoikis resistance to tumors. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2554.