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Microfluidic platform for controlling the differentiation of embryoid bodies

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Microfluidic platform for controlling the differentiation of embryoid bodies
นักวิจัย : Fung, Wai-To , Beyzavi, Ali , Abgrall, Patrick , Nguyen, Nam-Trung , Li, Hoi-Yeung
คำค้น : DRNTU::Engineering::Mechanical engineering
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2552
อ้างอิง : Fung, W. T., Beyzavi, A., Abgrall, P., Nguyen, N. T., & Li, H..Y. (2009). Microfluidic platform for controlling the differentiation of embryoid body. Lab on a Chip, 9(17), 2591–2595. , http://hdl.handle.net/10220/7751 , http://dx.doi.org/10.1039/B903753E , 145508
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Lab on a chip
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Embryonic stem (ES) cells are pluripotent cells, which can differentiate into any cell type. This cell type has often been implicated as an eminent source of renewable cells for tissue regeneration and cellular replacement therapies. Studies on manipulation of the various differentiation pathways have been at the forefront of research. There are many ways in which ES cells can be differentiated. One of the most common techniques is to initiate the development of embryoid bodies (EBs) by in vitro aggregation of ES cells. Thereafter, EBs can be induced to undergo differentiation into various cell lineages. In this article, we present a microfluidic platform using biocompatible materials, which is suitable for culturing EBs. The platform is based on a Y-channel device with two inlets for two different culturing media. An EB is located across both streams. Using the laminar characteristics at low Reynolds number and high Peclet numbers, we have induced cell differentiation on half of the EB while maintaining the other half in un-induced stages. The results prove the potential of using microfluidic technology for manipulation of EBs and ES cells in tissue engineering.

บรรณานุกรม :
Fung, Wai-To , Beyzavi, Ali , Abgrall, Patrick , Nguyen, Nam-Trung , Li, Hoi-Yeung . (2552). Microfluidic platform for controlling the differentiation of embryoid bodies.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Fung, Wai-To , Beyzavi, Ali , Abgrall, Patrick , Nguyen, Nam-Trung , Li, Hoi-Yeung . 2552. "Microfluidic platform for controlling the differentiation of embryoid bodies".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Fung, Wai-To , Beyzavi, Ali , Abgrall, Patrick , Nguyen, Nam-Trung , Li, Hoi-Yeung . "Microfluidic platform for controlling the differentiation of embryoid bodies."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2552. Print.
Fung, Wai-To , Beyzavi, Ali , Abgrall, Patrick , Nguyen, Nam-Trung , Li, Hoi-Yeung . Microfluidic platform for controlling the differentiation of embryoid bodies. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2552.