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Involvement of PKC-alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Involvement of PKC-alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells
นักวิจัย : Xue, Renhao , Zhao, Yanying , Chen, Peng
คำค้น : DRNTU::Science::Medicine::Biomedical engineering
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2552
อ้างอิง : Xue, R., Zhao, Y., & Chen, P. (2009). Involvement of PKC-alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells. Biochemical and Biophysical Research Communications, 380(2), 371-376. , http://hdl.handle.net/10220/7524 , http://dx.doi.org/10.1016/j.bbrc.2009.01.105 , 149099
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Biochemical and biophysical research communications
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Phorbol-12-myristate-13-acetate, a stable analog of the important signaling membrane lipid diacylglycerol (DAG), is known to potentiate exocytosis and modulate vesicle fusion kinetics in neurons and endocrine cells. The exact mechanisms underlying the actions of PMA, however, is often not clear, largely because of the diversity of the DAG/PMA receptors involved in the exocytotic process, which include, most notably, various isoforms of protein kinase C (PKC). In this study, the roles of PKCa in PMA-mediated regulation of exocytosis were investigated by over-expressing wild-type PKCa (wt-PKCa) or dominant negative PKCa (dn-PKCa). Amperometric measurements based on carbon fiber microelectrodes demonstrated that PKCa has a key role in the PMA-mediated facilitation of exocytosis and vesicle fusion in neuroendocrine PC12 cells.

บรรณานุกรม :
Xue, Renhao , Zhao, Yanying , Chen, Peng . (2552). Involvement of PKC-alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Xue, Renhao , Zhao, Yanying , Chen, Peng . 2552. "Involvement of PKC-alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Xue, Renhao , Zhao, Yanying , Chen, Peng . "Involvement of PKC-alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2552. Print.
Xue, Renhao , Zhao, Yanying , Chen, Peng . Involvement of PKC-alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2552.