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PKC epsilon facilitates recovery of exocytosis after an exhausting stimulation

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : PKC epsilon facilitates recovery of exocytosis after an exhausting stimulation
นักวิจัย : Xue, Renhao , Zhao, Yanying , Su, Luanyu , Ye, Feng , Chen, Peng
คำค้น : DRNTU::Science::Medicine::Biomedical engineering
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2552
อ้างอิง : Xue, R., Zhao, Y., Su, L., Ye, F., & Chen, P. (2009). PKC epsilon facilitates recovery of exocytosis after an exhausting stimulation. Pflügers Archiv European Journal of Physiology, 458(6), 1137-1149. , http://hdl.handle.net/10220/7523 , http://dx.doi.org/10.1007/s00424-009-0697-4 , 149066
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Pflügers archiv European journal of physiology
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

It has been well documented that protein kinase Cs (PKCs) play multifaceted roles in regulating exocytosis of neurotransmitters and hormones. But the isoform-specific PKC effects are still poorly elucidated mainly because of the large variety of PKC isoforms and the dubious specificity of the commonly used pharmacological agents. In the present study, based on overexpression of wild-type or dominant negative PKCε, we demonstrate in neuroendocrine PC12 cells that PKCε, but not PKCα, facilitates recovery of exocytosis after an exhausting stimulation. Specifically, PKCε mediates fast recovery of the extent of exocytosis in a phosphatidylinositol biphosphate-dependent manner, likely through enhancing the rate of vesicle delivery and reorganization of cortical actin network. In addition, PKCε promotes fast recovery of vesicle release kinetics that is slowed after a strong stimulation. These experimental results may suggest a PKC-dependent mechanism relevant to the short-term plasticity of exocytosis in both neurons and neuroendocrine cells.

บรรณานุกรม :
Xue, Renhao , Zhao, Yanying , Su, Luanyu , Ye, Feng , Chen, Peng . (2552). PKC epsilon facilitates recovery of exocytosis after an exhausting stimulation.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Xue, Renhao , Zhao, Yanying , Su, Luanyu , Ye, Feng , Chen, Peng . 2552. "PKC epsilon facilitates recovery of exocytosis after an exhausting stimulation".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Xue, Renhao , Zhao, Yanying , Su, Luanyu , Ye, Feng , Chen, Peng . "PKC epsilon facilitates recovery of exocytosis after an exhausting stimulation."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2552. Print.
Xue, Renhao , Zhao, Yanying , Su, Luanyu , Ye, Feng , Chen, Peng . PKC epsilon facilitates recovery of exocytosis after an exhausting stimulation. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2552.