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Effects of phorbol ester on vesicle dynamics as revealed by total internal reflection fluorescence microscopy

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Effects of phorbol ester on vesicle dynamics as revealed by total internal reflection fluorescence microscopy
นักวิจัย : Zhang, Enming , Xue, Renhao , Soo, Jianchow , Chen, Peng
คำค้น : DRNTU::Science::Medicine::Biomedical engineering
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2551
อ้างอิง : Zhang, E., Xue, R., Soo, J. & Chen, P. (2008). Effects of phorbol ester on vesicle dynamics as revealed by total internal reflection fluorescence microscopy. Pflügers Archiv European Journal of Physiology, 457, 211-222. , http://hdl.handle.net/10220/7522 , http://dx.doi.org/10.1007/s00424-008-0485-6 , 118348
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Pflügers archiv European journal of physiology
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Exocytosis of neurotransmitter or hormone-filled vesicles is a highly dynamic process regulated by various proteins and lipids. As mainly revealed indirectly by the electrophysiological methods, exocytosis is believed to involve multiple kinetic steps in which vesicles transit from one state to another. Using total internal reflection fluorescence microscopy which enables direct visualization of individual vesicles, we developed an analytical framework to track and analyze vesicle dynamics. We demonstrated that all subplasmalemmal vesicles generally undergo constant and caged Brownian motion. And they can be classified into three populations that differ in their motion characteristics and fusion competence. Furthermore, we showed that these vesicle pools are differentially modulated by phorbol-12-myristate-13-acetate, a phorbol ester analog to endogenous diacylglycerol, through both protein-kinase- C-dependent and -independent pathways.

บรรณานุกรม :
Zhang, Enming , Xue, Renhao , Soo, Jianchow , Chen, Peng . (2551). Effects of phorbol ester on vesicle dynamics as revealed by total internal reflection fluorescence microscopy.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhang, Enming , Xue, Renhao , Soo, Jianchow , Chen, Peng . 2551. "Effects of phorbol ester on vesicle dynamics as revealed by total internal reflection fluorescence microscopy".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhang, Enming , Xue, Renhao , Soo, Jianchow , Chen, Peng . "Effects of phorbol ester on vesicle dynamics as revealed by total internal reflection fluorescence microscopy."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2551. Print.
Zhang, Enming , Xue, Renhao , Soo, Jianchow , Chen, Peng . Effects of phorbol ester on vesicle dynamics as revealed by total internal reflection fluorescence microscopy. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2551.