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Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays
นักวิจัย : Ye, Feng , Than, Aung , Zhao, Yanying , Goh, Kian Hong , Chen, Peng
คำค้น : DRNTU::Science::Medicine::Biomedical engineering
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2553
อ้างอิง : Ye, F., Than, A., Zhao, Y., Goh, K. H. & Chen, P. (2010). Vesicular storage, vesicle trafficking, and secretion of leptin and resistin: the similarities, differences and interplays. Journal of Endocrinology, 206, 27–36. , http://hdl.handle.net/10220/7502 , http://dx.doi.org/10.1677/JOE-10-0090 , 153339
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of endocrinology
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Adipose tissue is a highly active endocrine organ secreting a variety of signaling molecules called adipokines. Leptin and resistin are two adipokines critically involved in metabolic homeostasis. Nevertheless, the secretory pathways of these adipokines and their interplays are poorly elucidated. In this work, we have comparatively studied several key aspects of leptin and resistin secretion from 3T3-L1 adipocytes. It was found that leptin and resistin molecules are compartmentalized into different secretory vesicles. The trafficking of leptin and resistin vesicles, and the secretion of leptin and resistin are oppositely regulated by insulin/glycolytic substrates and cAMP/protein kinase A. Interestingly, these two adipokines adversely influence each other on secretion and vesicle trafficking. Finally, we demonstrated that both leptin and resistin secretion are Ca2+ dependent.

บรรณานุกรม :
Ye, Feng , Than, Aung , Zhao, Yanying , Goh, Kian Hong , Chen, Peng . (2553). Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ye, Feng , Than, Aung , Zhao, Yanying , Goh, Kian Hong , Chen, Peng . 2553. "Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ye, Feng , Than, Aung , Zhao, Yanying , Goh, Kian Hong , Chen, Peng . "Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2553. Print.
Ye, Feng , Than, Aung , Zhao, Yanying , Goh, Kian Hong , Chen, Peng . Vesicular storage, vesicle trafficking, and secretion of leptin and resistin : the similarities, differences and interplays. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2553.