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Glycosylated porphyrin derivatives and their photodynamic activity in cancer cells

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Glycosylated porphyrin derivatives and their photodynamic activity in cancer cells
นักวิจัย : Vedachalam, Seenuvasan , Choi, Bo-Hwa , Pasunooti, Kalyan Kumar , Ching, Kun Mei , Lee, Kijoon , Yoon, Ho Sup , Liu, Xue-Wei
คำค้น : DRNTU::Science::Biological sciences::Cytology.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2554
อ้างอิง : Vedachalam, S., Choi, B. H., Pasunooti, K. K., Ching, K. M., Lee, K., Yoon, H. S. & Liu, X. W. (2011). Glycosylated prophyrin derivatives and their photodynamic activity in tumor cells. Med. Chem. Commun., 2, 371-377. , http://hdl.handle.net/10220/7483 , http://dx.doi.org/10.1039/c0md00175a
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Med. Chem. Commun.
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The present study reports the design and synthesis of nine C2-symmetric 5,15-[bis(arayl)]-10α,20β- [bis(1,2:3,4-di-O-isopropylidene-α-D-galactopyranose-6-yl)]porphyrins (3–11) bearing electron donating or electron withdrawing substituents and a D2-symmetric 5α,10β,15α,20β-tetrakis(1,2:3,4-di- O-isopropylidene-α-D-galactopyranose-6-yl)porphyrin (12). In the system we design, the C6 of pyranose sugar is elegantly fused into the porphyrin core as meso carbon, which renders a new type of photodynanic inducers. The biological effects of these derivatives were assessed in HeLa and HCT116 human cancer cells. In particular, the tetra-glycofused structure 12 exhibited the highest cellular uptake and photocytotoxicity. Unlike the reported sugar-porphyrin conjugates, which normally localize in mitochondria or endoplasmic reticulum, the unique glycofused porphyrins in this study were dominantly localized in lysosomes. The measurement of the dual flurorescence of annexin V-FITC/PI by flow cytometry revealed that the cell death was caused by apoptosis. Further PARP cleavage study suggested that apoptosis induced by the treatment of compound 12 was via caspase-dependent apoptotic pathway in cancer cells.

บรรณานุกรม :
Vedachalam, Seenuvasan , Choi, Bo-Hwa , Pasunooti, Kalyan Kumar , Ching, Kun Mei , Lee, Kijoon , Yoon, Ho Sup , Liu, Xue-Wei . (2554). Glycosylated porphyrin derivatives and their photodynamic activity in cancer cells.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Vedachalam, Seenuvasan , Choi, Bo-Hwa , Pasunooti, Kalyan Kumar , Ching, Kun Mei , Lee, Kijoon , Yoon, Ho Sup , Liu, Xue-Wei . 2554. "Glycosylated porphyrin derivatives and their photodynamic activity in cancer cells".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Vedachalam, Seenuvasan , Choi, Bo-Hwa , Pasunooti, Kalyan Kumar , Ching, Kun Mei , Lee, Kijoon , Yoon, Ho Sup , Liu, Xue-Wei . "Glycosylated porphyrin derivatives and their photodynamic activity in cancer cells."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2554. Print.
Vedachalam, Seenuvasan , Choi, Bo-Hwa , Pasunooti, Kalyan Kumar , Ching, Kun Mei , Lee, Kijoon , Yoon, Ho Sup , Liu, Xue-Wei . Glycosylated porphyrin derivatives and their photodynamic activity in cancer cells. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2554.