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Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor

หน่วยงาน Nanyang Technological University, Singapore

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ชื่อเรื่อง : Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor
นักวิจัย : Zhou, Ming-Ming , Meadows, Robert P. , Logan, Timothy M. , Yoon, Ho Sup , Wade, Warren S. , Ravichandran, Kodimangalam S. , Burakoffe, Steven J. , Fesik, Stephen W.
คำค้น : DRNTU::Science::Biological sciences.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2538
อ้างอิง : Zhou, M. M., Meadows, R. P., Logan, T. M., Yoon, H. S., Wade, W. S., Ravichandran, K. S., et al. (1995). Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor. Proceedings of the National Academy of Sciences, 92(17), 7784-7788. , http://hdl.handle.net/10220/7506 , http://dx.doi.org/10.1073/pnas.92.17.7784
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Shc is a widely expressed adapter protein that plays an important role in signaling via a variety of cell surface receptors and has been implicated in coupling the stimulation of growth factor, cytokine, and antigen receptors to the Ras signaling pathway. She interacts with several tyrosine-phosphorylated receptors through its C-terminal SH2 domain, and one of the mechanisms of T-cell receptor-mediated Ras activation involves the interaction of the Shc SH2 domain with the tyrosine-phosphorylated zeta chain of the T-cell receptor. Here we describe a high-resolution NMR structure of the Shc SH2 domain complexed to a phosphopeptide (GHDGLpYQGLSTATK) corresponding to a portion of the zeta chain of the T-cell receptor. Although the overall architecture of the protein is similar to other SH2 domains, distinct structural differences were observed in the smaller beta-sheet, BG loop, (pY + 3) phosphopeptide-binding site, and relative position of the bound phosphopeptide.

บรรณานุกรม :
Zhou, Ming-Ming , Meadows, Robert P. , Logan, Timothy M. , Yoon, Ho Sup , Wade, Warren S. , Ravichandran, Kodimangalam S. , Burakoffe, Steven J. , Fesik, Stephen W. . (2538). Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhou, Ming-Ming , Meadows, Robert P. , Logan, Timothy M. , Yoon, Ho Sup , Wade, Warren S. , Ravichandran, Kodimangalam S. , Burakoffe, Steven J. , Fesik, Stephen W. . 2538. "Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhou, Ming-Ming , Meadows, Robert P. , Logan, Timothy M. , Yoon, Ho Sup , Wade, Warren S. , Ravichandran, Kodimangalam S. , Burakoffe, Steven J. , Fesik, Stephen W. . "Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2538. Print.
Zhou, Ming-Ming , Meadows, Robert P. , Logan, Timothy M. , Yoon, Ho Sup , Wade, Warren S. , Ravichandran, Kodimangalam S. , Burakoffe, Steven J. , Fesik, Stephen W. . Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2538.