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Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites
นักวิจัย : Gao, Xiaohong , Yeo, Kim Pin , Aw, Sharon Siqi , Kuss, Claudia , Iyer, Jayasree K. , Genesan, Saraswathy , Rajamanonmani, Ravikumar , Lescar, Julien , Bozdech, Zbynek , Preiser, Peter Rainer
คำค้น : DRNTU::Science::Biological sciences::Microbiology::Immunology
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2551
อ้างอิง : Gao, X., Yeo, K. P., Aw, S. S., Kuss, C., Iyer, J. K., Genesan, S. & et al. (2008) Antibodies Targeting the PfRH1 Binding Domain Inhibit Invasion of Plasmodium falciparum Merozoites. PLoS Pathog, 4(7). , 1553-7366 , http://hdl.handle.net/10220/7060 , http://dx.doi.org/10.1371/journal.ppat.1000104 , 96210
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : PLoS pathogens
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Invasion by the malaria merozoite depends on recognition of specific erythrocyte surface receptors by parasite ligands. Plasmodium falciparum uses multiple ligands, including at least two gene families, reticulocyte binding protein homologues (RBLs) and erythrocyte binding proteins/ligands (EBLs). The combination of different RBLs and EBLs expressed in a merozoite defines the invasion pathway utilized and could also play a role in parasite virulence. The binding regions of EBLs lie in a conserved cysteine-rich domain while the binding domain of RBL is still not well characterized. Here, we identify the erythrocyte binding region of the P. falciparum reticulocyte binding protein homologue 1 (PfRH1) and show that antibodies raised against the functional binding region efficiently inhibit invasion. In addition, we directly demonstrate that changes in the expression of RBLs can constitute an immune evasion mechanism of the malaria merozoite.

บรรณานุกรม :
Gao, Xiaohong , Yeo, Kim Pin , Aw, Sharon Siqi , Kuss, Claudia , Iyer, Jayasree K. , Genesan, Saraswathy , Rajamanonmani, Ravikumar , Lescar, Julien , Bozdech, Zbynek , Preiser, Peter Rainer . (2551). Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Gao, Xiaohong , Yeo, Kim Pin , Aw, Sharon Siqi , Kuss, Claudia , Iyer, Jayasree K. , Genesan, Saraswathy , Rajamanonmani, Ravikumar , Lescar, Julien , Bozdech, Zbynek , Preiser, Peter Rainer . 2551. "Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Gao, Xiaohong , Yeo, Kim Pin , Aw, Sharon Siqi , Kuss, Claudia , Iyer, Jayasree K. , Genesan, Saraswathy , Rajamanonmani, Ravikumar , Lescar, Julien , Bozdech, Zbynek , Preiser, Peter Rainer . "Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2551. Print.
Gao, Xiaohong , Yeo, Kim Pin , Aw, Sharon Siqi , Kuss, Claudia , Iyer, Jayasree K. , Genesan, Saraswathy , Rajamanonmani, Ravikumar , Lescar, Julien , Bozdech, Zbynek , Preiser, Peter Rainer . Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2551.