ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Molecular binding behavior of pyridine-2,6-dicarboxamide-bridged bis(β-cyclodextrin) with oligopeptides : switchable molecular binding mode

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Molecular binding behavior of pyridine-2,6-dicarboxamide-bridged bis(β-cyclodextrin) with oligopeptides : switchable molecular binding mode
นักวิจัย : Liu, Yu , Chen, Guo Song , Chen, Yong , Ding, Fei , Liu, Tao , Zhao, Yanli
คำค้น : DRNTU::Science::Biological sciences::Biochemistry.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2547
อ้างอิง : Liu, Y., Chen, G. S., Chen, Y., Ding, F., Liu, T., & Zhao, Y. L. (2004). Molecular Binding Behavior of Pyridine-2,6-dicarboxamide-Bridged Bis(β-cyclodextrin) with Oligopeptides: Switchable Molecular Binding Mode. Bioconjugate Chemistry, 15(2), 300-306. , http://hdl.handle.net/10220/7035 , http://dx.doi.org/10.1021/bc034230p , 159654
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Bioconjugate chemistry
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Bridged bis(β-cyclodextrin) 1 with a pyridine-2,6-dicarboxamide linker was synthesized, and its inclusion complexation behavior with some aliphatic oligopeptides was investigated in aqueous buffer solution of pH 2.0 and 7.2 at 25 °C by means of circular dichroism, fluorescence, and 2D NMR techniques. The results show that the resulting inclusion complexes of 1 with oligopeptides adopt a cooperative “cyclodextrin-guest-cyclodextrin” sandwich binding mode in a neutral media, but a “guest-linker-cyclodextrin” coinclusion binding mode in an acidic media. These switchable binding modes consequently rationalize the binding ability of bis(β -cyclodextrin) 1 at different pH values; that is, 1 shows the stronger association with oligopeptides in a neutral media. Because of the simultaneous contributions of hydrophobic, hydrogen bond, and electrostatic interactions, bis(β-cyclodextrin) 1 affords length-selectivity up to 4.7 for the Gly-Gly/Gly-Gly-Gly pair at pH 2.0 and sequence-selectivity up to 4.2 for the Gly-Leu/Leu-Gly pair at pH 7.2. These phenomena are discussed from the viewpoint of the size-fit concept and the multipoint recognitions between host and guest.

บรรณานุกรม :
Liu, Yu , Chen, Guo Song , Chen, Yong , Ding, Fei , Liu, Tao , Zhao, Yanli . (2547). Molecular binding behavior of pyridine-2,6-dicarboxamide-bridged bis(β-cyclodextrin) with oligopeptides : switchable molecular binding mode.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Liu, Yu , Chen, Guo Song , Chen, Yong , Ding, Fei , Liu, Tao , Zhao, Yanli . 2547. "Molecular binding behavior of pyridine-2,6-dicarboxamide-bridged bis(β-cyclodextrin) with oligopeptides : switchable molecular binding mode".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Liu, Yu , Chen, Guo Song , Chen, Yong , Ding, Fei , Liu, Tao , Zhao, Yanli . "Molecular binding behavior of pyridine-2,6-dicarboxamide-bridged bis(β-cyclodextrin) with oligopeptides : switchable molecular binding mode."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2547. Print.
Liu, Yu , Chen, Guo Song , Chen, Yong , Ding, Fei , Liu, Tao , Zhao, Yanli . Molecular binding behavior of pyridine-2,6-dicarboxamide-bridged bis(β-cyclodextrin) with oligopeptides : switchable molecular binding mode. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2547.