ชื่อเรื่อง | : | The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells |
นักวิจัย | : | Ogata, Hirotaka , Su, I. Hsin , Nagai, Yoshinor , Akashi, Sachiko , Mecklenbräuker, Ingrid , Rajewsky, Klaus , Kimoto, Masao , Tarakhovsky, Alexander |
คำค้น | : | DRNTU::Science::Biological sciences::Molecular biology |
หน่วยงาน | : | Nanyang Technological University, Singapore |
ผู้ร่วมงาน | : | - |
ปีพิมพ์ | : | 2543 |
อ้างอิง | : | Ogata, H., Su, I. H., Nagai, Y., Akashi, S., Mecklenbräuker, I., Rajewsky, K., et al. (2000). The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. Journal of experimental medicine, 192(1), 23-29. , http://hdl.handle.net/10220/6799 , http://dx.doi.org/10.1084/jem.192.1.23 |
ที่มา | : | - |
ความเชี่ยวชาญ | : | - |
ความสัมพันธ์ | : | Journal of experimental medicine |
ขอบเขตของเนื้อหา | : | - |
บทคัดย่อ/คำอธิบาย | : | The susceptibility to infections induced by Gram-negative bacteria is largely determined by innate immune responses to bacteria cell wall lipopolysaccharide (LPS). The stimulation of B cells by LPS enhances their antigen-presenting capacity and is accompanied by B cell proliferation and secretion of large quantities of LPS-neutralizing antibodies. Similar to macrophages and neutrophils, the LPS-induced activation of B cells is dependent on Toll-like receptor (TLR)4. Here, we demonstrate that the responses of B cells to LPS are also regulated by another TLR protein, RP105, which is predominantly expressed on mature B cells in mice and humans. The analysis of mice homozygous for the null mutation in the RP105 gene revealed impaired proliferative and humoral immune responses of RP105-deficient B cells to LPS. Using originally LPS-unresponsive Ba/F3 cells expressing exogenous TLR4 and RP105, we demonstrate the functional cooperation between TLR4 and RP105 in LPS-induced nuclear factor kB activation. These data suggest the existence of the TLR4–RP105 signaling module in the LPS-induced B cell activation. |
บรรณานุกรม | : |
Ogata, Hirotaka , Su, I. Hsin , Nagai, Yoshinor , Akashi, Sachiko , Mecklenbräuker, Ingrid , Rajewsky, Klaus , Kimoto, Masao , Tarakhovsky, Alexander . (2543). The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Ogata, Hirotaka , Su, I. Hsin , Nagai, Yoshinor , Akashi, Sachiko , Mecklenbräuker, Ingrid , Rajewsky, Klaus , Kimoto, Masao , Tarakhovsky, Alexander . 2543. "The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Ogata, Hirotaka , Su, I. Hsin , Nagai, Yoshinor , Akashi, Sachiko , Mecklenbräuker, Ingrid , Rajewsky, Klaus , Kimoto, Masao , Tarakhovsky, Alexander . "The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2543. Print. Ogata, Hirotaka , Su, I. Hsin , Nagai, Yoshinor , Akashi, Sachiko , Mecklenbräuker, Ingrid , Rajewsky, Klaus , Kimoto, Masao , Tarakhovsky, Alexander . The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2543.
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