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The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells

หน่วยงาน Nanyang Technological University, Singapore

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ชื่อเรื่อง : The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells
นักวิจัย : Ogata, Hirotaka , Su, I. Hsin , Nagai, Yoshinor , Akashi, Sachiko , Mecklenbräuker, Ingrid , Rajewsky, Klaus , Kimoto, Masao , Tarakhovsky, Alexander
คำค้น : DRNTU::Science::Biological sciences::Molecular biology
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2543
อ้างอิง : Ogata, H., Su, I. H., Nagai, Y., Akashi, S., Mecklenbräuker, I., Rajewsky, K., et al. (2000). The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. Journal of experimental medicine, 192(1), 23-29. , http://hdl.handle.net/10220/6799 , http://dx.doi.org/10.1084/jem.192.1.23
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of experimental medicine
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The susceptibility to infections induced by Gram-negative bacteria is largely determined by innate immune responses to bacteria cell wall lipopolysaccharide (LPS). The stimulation of B cells by LPS enhances their antigen-presenting capacity and is accompanied by B cell proliferation and secretion of large quantities of LPS-neutralizing antibodies. Similar to macrophages and neutrophils, the LPS-induced activation of B cells is dependent on Toll-like receptor (TLR)4. Here, we demonstrate that the responses of B cells to LPS are also regulated by another TLR protein, RP105, which is predominantly expressed on mature B cells in mice and humans. The analysis of mice homozygous for the null mutation in the RP105 gene revealed impaired proliferative and humoral immune responses of RP105-deficient B cells to LPS. Using originally LPS-unresponsive Ba/F3 cells expressing exogenous TLR4 and RP105, we demonstrate the functional cooperation between TLR4 and RP105 in LPS-induced nuclear factor kB activation. These data suggest the existence of the TLR4–RP105 signaling module in the LPS-induced B cell activation.

บรรณานุกรม :
Ogata, Hirotaka , Su, I. Hsin , Nagai, Yoshinor , Akashi, Sachiko , Mecklenbräuker, Ingrid , Rajewsky, Klaus , Kimoto, Masao , Tarakhovsky, Alexander . (2543). The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ogata, Hirotaka , Su, I. Hsin , Nagai, Yoshinor , Akashi, Sachiko , Mecklenbräuker, Ingrid , Rajewsky, Klaus , Kimoto, Masao , Tarakhovsky, Alexander . 2543. "The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ogata, Hirotaka , Su, I. Hsin , Nagai, Yoshinor , Akashi, Sachiko , Mecklenbräuker, Ingrid , Rajewsky, Klaus , Kimoto, Masao , Tarakhovsky, Alexander . "The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2543. Print.
Ogata, Hirotaka , Su, I. Hsin , Nagai, Yoshinor , Akashi, Sachiko , Mecklenbräuker, Ingrid , Rajewsky, Klaus , Kimoto, Masao , Tarakhovsky, Alexander . The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2543.