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The molecular mechanism of B cell activation by toll-like receptor protein RP-105.

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : The molecular mechanism of B cell activation by toll-like receptor protein RP-105.
นักวิจัย : Chan, Vivien W. F. , Mecklenbräuker, Ingrid. , Su, I. Hsin. , Texido, Gemma. , Leitges, Michael. , Carsetti, Rita. , Lowell, Clifford A. , Rajewsky, Klaus. , Miyake, Kensuke. , Tarakhovsky, Alexander.
คำค้น : DRNTU::Science::Biological sciences::Molecular biology.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2541
อ้างอิง : Chan, V. W. F., Mecklenbräuker, I., Su, I. H., Texido, G., Leitges, M., Carsetti, R., et al. (1998). The molecular mechanism of B cell activation by toll-like receptor protein RP-105. Journal of experimental medicine, 188(1), 93-101. , http://hdl.handle.net/10220/6798 , http://dx.doi.org/10.1084/jem.188.1.93
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of experimental medicine
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The B cell–specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like proteins which are likely to trigger innate immune responses in mice and man. Here we demonstrate that the Src-family protein tyrosine kinase Lyn, protein kinase C b I/II (PKC bI/II), and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) are essential and probably functionally connected elements of the RP-105–mediated signaling cascade in B cells. We also find that negative regulation of RP-105–mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor–mediated arrest of RP-105–mediated B cell proliferation.

บรรณานุกรม :
Chan, Vivien W. F. , Mecklenbräuker, Ingrid. , Su, I. Hsin. , Texido, Gemma. , Leitges, Michael. , Carsetti, Rita. , Lowell, Clifford A. , Rajewsky, Klaus. , Miyake, Kensuke. , Tarakhovsky, Alexander. . (2541). The molecular mechanism of B cell activation by toll-like receptor protein RP-105..
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chan, Vivien W. F. , Mecklenbräuker, Ingrid. , Su, I. Hsin. , Texido, Gemma. , Leitges, Michael. , Carsetti, Rita. , Lowell, Clifford A. , Rajewsky, Klaus. , Miyake, Kensuke. , Tarakhovsky, Alexander. . 2541. "The molecular mechanism of B cell activation by toll-like receptor protein RP-105.".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chan, Vivien W. F. , Mecklenbräuker, Ingrid. , Su, I. Hsin. , Texido, Gemma. , Leitges, Michael. , Carsetti, Rita. , Lowell, Clifford A. , Rajewsky, Klaus. , Miyake, Kensuke. , Tarakhovsky, Alexander. . "The molecular mechanism of B cell activation by toll-like receptor protein RP-105.."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2541. Print.
Chan, Vivien W. F. , Mecklenbräuker, Ingrid. , Su, I. Hsin. , Texido, Gemma. , Leitges, Michael. , Carsetti, Rita. , Lowell, Clifford A. , Rajewsky, Klaus. , Miyake, Kensuke. , Tarakhovsky, Alexander. . The molecular mechanism of B cell activation by toll-like receptor protein RP-105.. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2541.