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Interleukin-6 and neural stem cells : more than gliogenesis

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Interleukin-6 and neural stem cells : more than gliogenesis
นักวิจัย : Omedul Islam , Gong, Xian Di , Rose-John, Stefan , Heese, Klaus
คำค้น : DRNTU::Science::Biological sciences::Microbiology::Immunology
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2552
อ้างอิง : Omedul I., Gong, X., Rose-John, S., & Heese, K. (2009). Interleukin-6 and Neural Stem Cells: more than Gliogenesis. Molecular Biology of the Cell, 20, 188-199. , 1059-1524 , http://hdl.handle.net/10220/6200 , http://dx.doi.org/10.1091/mbc.E08-05-0463
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Molecular biology of the cell
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Besides its wide range of action as a proinflammatory cytokine in the immune system, interleukin-6 (IL-6) has also attracted much attention due to its influence on the nervous system. In the present study we show that the designer fusion protein H-IL-6, consisting of IL-6 and its specific receptor IL-6R-α, but not IL-6 alone, mediates both neuro- as well as gliogenesis. Using immunocytochemistry, Western blot, and patch-clamp recording, we demonstrate that H-IL-6 induces the differentiation of neural stem cells (NSCs) specifically into glutamate-responsive neurons and two morphological distinctive astroglia cell types. H-IL-6–activated neurogenesis seems to be induced by the MAPK/CREB (mitogenactivated protein kinase/cAMP response element-binding protein) cascade, whereas gliogenesis is mediated via the STAT-3 (signal transducers and activators of transcription protein-3) signaling pathway. Our finding that IL-6 mediates both processes depending on its specific soluble receptor sIL-6R-α has implications for the potential treatment of neurodegenerative diseases.

บรรณานุกรม :
Omedul Islam , Gong, Xian Di , Rose-John, Stefan , Heese, Klaus . (2552). Interleukin-6 and neural stem cells : more than gliogenesis.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Omedul Islam , Gong, Xian Di , Rose-John, Stefan , Heese, Klaus . 2552. "Interleukin-6 and neural stem cells : more than gliogenesis".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Omedul Islam , Gong, Xian Di , Rose-John, Stefan , Heese, Klaus . "Interleukin-6 and neural stem cells : more than gliogenesis."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2552. Print.
Omedul Islam , Gong, Xian Di , Rose-John, Stefan , Heese, Klaus . Interleukin-6 and neural stem cells : more than gliogenesis. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2552.