ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Neurotrophins : more than Neurotrophic

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Neurotrophins : more than Neurotrophic
นักวิจัย : Shamini Ayyadhury , Heese, Klaus
คำค้น : DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2550
อ้างอิง : Shamini, A., & Heese, K. (2007). Neurotrophins: more than neurotrophic. Current Immunology Reviews, 3(3), 189-215. , 1573-3955 , http://hdl.handle.net/10220/6201 , http://www.ingentaconnect.com/content/ben/cir/2007/00000003/00000003/art00004
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Current immunology reviews
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The Nerve Growth Factor (NGF) is the prototypic member of the neurotrophin (NT) family, which plays an essential role in the development and functioning of the vertebrate nervous system. Although originally defined by their actions on neuronal survival and differentiation in the peripheral (PNS) and central nervous systems (CNS), accumulating data indicate the presence of extensive interactions between the NTs and the immune system. NTs are released normally during lymphocyte and leukocyte development by the bone marrow and the thymus and later by secondary lymph organs to maintain responsiveness of these circulating naïve and memory immune cells. Functional NT receptors have been detected on the cells of the immune system and increased levels of NGF protein are found during the acute phase of various diseases with a significant inflammatory component. Furthermore, in certain conditions such as allergic asthma, the released NTs exacerbate the severity of the inflammation and prolong the diseased state. However, in the CNS, if one can control homeostasis of the internal environment, then the natural response of the infiltrating immune cells to release these NTs can be used to intervene at key points in the disease progression. These wider functions are likely to be of concern in any attempted therapeutic use of NGF or related NTs.

บรรณานุกรม :
Shamini Ayyadhury , Heese, Klaus . (2550). Neurotrophins : more than Neurotrophic.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Shamini Ayyadhury , Heese, Klaus . 2550. "Neurotrophins : more than Neurotrophic".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Shamini Ayyadhury , Heese, Klaus . "Neurotrophins : more than Neurotrophic."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2550. Print.
Shamini Ayyadhury , Heese, Klaus . Neurotrophins : more than Neurotrophic. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2550.