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Allotypes of the Fouth Component of Complement (C4) in Normal Thai and Patients with Systemic Lupus Erythematosus (SLE), Dengue Haemorrhagic Fever (DHF), anf IgM Nephropathy

หน่วยงาน ฐานข้อมูลวิทยานิพนธ์ไทย

รายละเอียด

ชื่อเรื่อง : Allotypes of the Fouth Component of Complement (C4) in Normal Thai and Patients with Systemic Lupus Erythematosus (SLE), Dengue Haemorrhagic Fever (DHF), anf IgM Nephropathy
นักวิจัย : Suchat Udomsopagit
คำค้น : -
หน่วยงาน : ฐานข้อมูลวิทยานิพนธ์ไทย
ผู้ร่วมงาน : -
ปีพิมพ์ : 2532
อ้างอิง : http://www.thaithesis.org/detail.php?id=38512
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

A new technique of C4 allotyping based on elertro-transfer of C4 protein from agarose gel to nitrocellulose membrane had been developed. Neuraminidase and carboxypeptidase - treated - EDTA plasma was electrophoresed on agarose gel and was then eletrophoretically blotted onto nitrocellulose membrane. Bands of C4 were identified by immuno-enzyme technique with monospecific anti-C4. This technique allows the use of very high dilution of anti-C4 (1:1,00) antibody and enable the identification of isotype by the use of monoclonal antibody to the alpha chain. C4 allotyping in 97 patients with systemic lupus erythematosus (SLE), 39 with Dengue Haemorrhagic Fever (DHF), and 48 with IgM nephropathy were investigated. The C4 allotypes obtained were compared with data from 134 normal Thais. C4AQ0 and C4BQ0 were significantly increased in SLE (p = 0.0086 with relative risk (RR) of 5.02 and p = .0033 with RR of 3.22 respectively). C4B96 was significantly increased in mesangial IgM nephropathy (p = 0.0416 with RR of 5.40). C4B3 was found in greater frequencies in patients with DHF (p = 0.1837, RR = 3.57) and IgM nephropathy (p = 0.0227, RR = 6.00) as compared with control group. The results confirm the assoclation of null alleles of both isotypes with SLE and renders weight to the hypothesis that relative deficiency, in the form of null alleles might result in the mild inefficiency of the complement system leading to the defect in clearing antigen antibody complexes, resulting in the generation of immune complex disease. The fact that one allotype (C4B3) was found to be associated with DHF, a disease whose main pathophysiology indicates a "hyperactive" complement system, is the first tentative evidence that some allotypes are more functionally active than others. This fact remains still to be proven.

บรรณานุกรม :
Suchat Udomsopagit . (2532). Allotypes of the Fouth Component of Complement (C4) in Normal Thai and Patients with Systemic Lupus Erythematosus (SLE), Dengue Haemorrhagic Fever (DHF), anf IgM Nephropathy.
    กรุงเทพมหานคร : ฐานข้อมูลวิทยานิพนธ์ไทย.
Suchat Udomsopagit . 2532. "Allotypes of the Fouth Component of Complement (C4) in Normal Thai and Patients with Systemic Lupus Erythematosus (SLE), Dengue Haemorrhagic Fever (DHF), anf IgM Nephropathy".
    กรุงเทพมหานคร : ฐานข้อมูลวิทยานิพนธ์ไทย.
Suchat Udomsopagit . "Allotypes of the Fouth Component of Complement (C4) in Normal Thai and Patients with Systemic Lupus Erythematosus (SLE), Dengue Haemorrhagic Fever (DHF), anf IgM Nephropathy."
    กรุงเทพมหานคร : ฐานข้อมูลวิทยานิพนธ์ไทย, 2532. Print.
Suchat Udomsopagit . Allotypes of the Fouth Component of Complement (C4) in Normal Thai and Patients with Systemic Lupus Erythematosus (SLE), Dengue Haemorrhagic Fever (DHF), anf IgM Nephropathy. กรุงเทพมหานคร : ฐานข้อมูลวิทยานิพนธ์ไทย; 2532.