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Molecular characterization, evolution and cross-species transmission study in severe combined immunodeficiency transgenic mice with human hepatocytes of gibbon and orangutan hepatitis B virus

หน่วยงาน จุฬาลงกรณ์มหาวิทยาลัย

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ชื่อเรื่อง : Molecular characterization, evolution and cross-species transmission study in severe combined immunodeficiency transgenic mice with human hepatocytes of gibbon and orangutan hepatitis B virus
นักวิจัย : Pattaratida Sa-nguanmoo
คำค้น : Hepatitis B virus , Hepatitis B virus -- Transmission
หน่วยงาน : จุฬาลงกรณ์มหาวิทยาลัย
ผู้ร่วมงาน : Yong Poovorawan , Chulalongkorn University. Graduate School
ปีพิมพ์ : 2552
อ้างอิง : http://cuir.car.chula.ac.th/handle/123456789/16640
ที่มา : -
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ความสัมพันธ์ : -
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บทคัดย่อ/คำอธิบาย :

Thesis (Ph.D.)--Chulalongkorn University, 2009

Hepatitis B virus does not only exclusively infect humans, but also can be found in non-human primates. The genome organization of non-human primate HBV is nearly identical to that human HBV. There are the data on cross-species transmission of human HBVs to the non-human primates. However, a cross-species transmission of HBVs from non-human primates to human has not been yet been elucidated. One hundred and four non-human primates comprising 12 species were subjected to screen for the serological HBsAg, anti-HBs and anti-HBc markers. Subsequently, HBV DNA detection, whole genome characterization, phylogenetic analysis and evolution study were evaluated and analyzed. The cross-species transmission study in severe combined immunodeficiency (SCID) mice with human hepatocytes was performed. HBV infection was detected in gibbon (5/25) and orangutan (7/54). Phylogenetic analysis was performed and analyzed. The gibbon and orangutan viruses clustered within their respective groups. Evolutionary study revealed that the population growth rate of non-human primate HBV started a rapid increase in the effective population size around year 1750 to 1850. GiHBV was occurred before OuHBV and has evolutionary rate approximately 10[superscript -4] subs/site/year. OuHBV and GiHBV can replicate in chimeric SCID mice with human hepatocytes. The results showed indirect evidence of cross-species transmission of non-human primate to human could be occurred.

บรรณานุกรม :
Pattaratida Sa-nguanmoo . (2552). Molecular characterization, evolution and cross-species transmission study in severe combined immunodeficiency transgenic mice with human hepatocytes of gibbon and orangutan hepatitis B virus.
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Pattaratida Sa-nguanmoo . 2552. "Molecular characterization, evolution and cross-species transmission study in severe combined immunodeficiency transgenic mice with human hepatocytes of gibbon and orangutan hepatitis B virus".
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Pattaratida Sa-nguanmoo . "Molecular characterization, evolution and cross-species transmission study in severe combined immunodeficiency transgenic mice with human hepatocytes of gibbon and orangutan hepatitis B virus."
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย, 2552. Print.
Pattaratida Sa-nguanmoo . Molecular characterization, evolution and cross-species transmission study in severe combined immunodeficiency transgenic mice with human hepatocytes of gibbon and orangutan hepatitis B virus. กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย; 2552.