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Controlled release of testosterone and estradiol-17 β from biodegradable cylinders.

หน่วยงาน Southeast Asian Fisheries Development Center, Philippines

รายละเอียด

ชื่อเรื่อง : Controlled release of testosterone and estradiol-17 β from biodegradable cylinders.
นักวิจัย : Zhang, X. , Wyss, U.P. , Pichora, D. , Goosen, M.F.A. , Gonzal, A. , Marte, C.L.
คำค้น : Testosterone , Estradiol-17 β , Biodegradable cylinder , Diffusion coefficient
หน่วยงาน : Southeast Asian Fisheries Development Center, Philippines
ผู้ร่วมงาน : -
ปีพิมพ์ : 2537
อ้างอิง : Zhang, X., Wyss, U. P., Pichora, D., Goosen, M. F. A., Gonzal, A., & Marte, C. L. (1994). Controlled release of testosterone and estradiol-17 β from biodegradable cylinders. Journal of Controlled Release, 29(1–2), 157–161. , 0168-3659 , http://hdl.handle.net/10862/1467 , 10.1016/0168-3659(94)90131-7
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of Controlled Release
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

A controlled release device for the hormones, testosterone and estradiol-17 β, was developed by coating a melt extruded hormone/poly (ϵ-caprolactone) cylinder with pure polylactide. Since testosterone and estradiol-17β have much higher permeabilities in poly (ϵ-caprolactone) than in polylactide, they primarily permeate through the open ends of the cylinder, with little release through the polylactide wall. By changing the cylinder length, the release rate and duration could be adjusted. The release followed Pick's diffusion equation for a drug loading below its solubility in poly (ϵ-caprolactone) or Higuchi's equation for a drug loading above the solubility. The diffusion coefficients of testosterone and estradiol-17β in poly (ϵ-caprolactone) were estimated as (8.31 ±3.12) × 10−18 and (0.728 ± 0.250) × 10−18 cm2/s, respectively.

บรรณานุกรม :
Zhang, X. , Wyss, U.P. , Pichora, D. , Goosen, M.F.A. , Gonzal, A. , Marte, C.L. . (2537). Controlled release of testosterone and estradiol-17 β from biodegradable cylinders..
    : Southeast Asian Fisheries Development Center, Philippines.
Zhang, X. , Wyss, U.P. , Pichora, D. , Goosen, M.F.A. , Gonzal, A. , Marte, C.L. . 2537. "Controlled release of testosterone and estradiol-17 β from biodegradable cylinders.".
    : Southeast Asian Fisheries Development Center, Philippines.
Zhang, X. , Wyss, U.P. , Pichora, D. , Goosen, M.F.A. , Gonzal, A. , Marte, C.L. . "Controlled release of testosterone and estradiol-17 β from biodegradable cylinders.."
    : Southeast Asian Fisheries Development Center, Philippines, 2537. Print.
Zhang, X. , Wyss, U.P. , Pichora, D. , Goosen, M.F.A. , Gonzal, A. , Marte, C.L. . Controlled release of testosterone and estradiol-17 β from biodegradable cylinders.. : Southeast Asian Fisheries Development Center, Philippines; 2537.