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Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats

หน่วยงาน Universiti Sains Malaysia, Malaysia

รายละเอียด

ชื่อเรื่อง : Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats
นักวิจัย : Mohamed, Elsnoussi Ali , Ahmad, Mariam , Lee, Fung Ang , Asmawi, Mohd. Zaini , Mun, Fei Yam
คำค้น : RS1-441 Pharmacy and materia medica
หน่วยงาน : Universiti Sains Malaysia, Malaysia
ผู้ร่วมงาน : -
ปีพิมพ์ : 2558
อ้างอิง : http://eprints.usm.my/39039/1/Evaluation_of_%CE%B1%2DGlucosidase_Inhibitory_Effect_of_50%25_Ethanolic_Standardized.pdf , Mohamed, Elsnoussi Ali and Ahmad, Mariam and Lee, Fung Ang and Asmawi, Mohd. Zaini and Mun, Fei Yam (2015) Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine, 2015 (754931). pp. 1-6. ISSN 1741-427X
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : http://dx.doi.org/10.1155/2015/754931 , http://eprints.usm.my/39039/
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

In the present study, a 50% ethanolic extract of Orthosiphon stamineus was tested for its α-glucosidase inhibitory activity. In vivo assays of the extract (containing 1.02%, 3.76%, and 3.03% of 3′hydroxy-5,6,7,4′-tetramethoxyflavone, sinensetin, and eupatorin, resp.) showed that it possessed an inhibitory activity against α-glucosidase in normal rats loaded with starch and sucrose. The results showed that 1000 mg/kg of the 50% ethanolic extract of O. stamineus significantly () decreased the plasma glucose levels of the experimental animals in a manner resembling the effect of acarbose. In streptozotocin-induced diabetic rats, only the group treated with 1000 mg/kg of the extract showed significantly () lower plasma glucose levels after starch loading. Hence, α-glucosidase inhibition might be one of the mechanisms by which O. stamineus extract exerts its antidiabetic effect. Furthermore, our findings indicated that the 50% ethanolic extract of O. stamineus can be considered as a potential agent for the management of diabetes mellitus.

บรรณานุกรม :
Mohamed, Elsnoussi Ali , Ahmad, Mariam , Lee, Fung Ang , Asmawi, Mohd. Zaini , Mun, Fei Yam . (2558). Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats.
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
Mohamed, Elsnoussi Ali , Ahmad, Mariam , Lee, Fung Ang , Asmawi, Mohd. Zaini , Mun, Fei Yam . 2558. "Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats".
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
Mohamed, Elsnoussi Ali , Ahmad, Mariam , Lee, Fung Ang , Asmawi, Mohd. Zaini , Mun, Fei Yam . "Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats."
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia, 2558. Print.
Mohamed, Elsnoussi Ali , Ahmad, Mariam , Lee, Fung Ang , Asmawi, Mohd. Zaini , Mun, Fei Yam . Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats. กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia; 2558.