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Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities

หน่วยงาน Universiti Sains Malaysia, Malaysia

รายละเอียด

ชื่อเรื่อง : Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities
นักวิจัย : C. S., Chidan Kumar , Li, Yee Then , Tze, Shyang Chia , Chandraju, Siddegowda , Win, Yip Foo , Sulaiman, Shaida Fariza , Hashim, Nurul Shafiqah , Kheng, Leong Ooi , Ching, Kheng Quah , Fun, Hoong Kun
คำค้น : QC1-999 Physics , QH1 Natural history (General - Including nature conservation, geographical distribution)
หน่วยงาน : Universiti Sains Malaysia, Malaysia
ผู้ร่วมงาน : -
ปีพิมพ์ : 2558
อ้างอิง : http://eprints.usm.my/38388/1/Benzofuranyl_Esters_Synthesis%2C_Crystal_Structure_Determination.pdf , C. S., Chidan Kumar and Li, Yee Then and Tze, Shyang Chia and Chandraju, Siddegowda and Win, Yip Foo and Sulaiman, Shaida Fariza and Hashim, Nurul Shafiqah and Kheng, Leong Ooi and Ching, Kheng Quah and Fun, Hoong Kun (2015) Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities. Molecules, 20 (9). pp. 16566-16581. ISSN 1420-3049
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : https://doi.org/10.3390/molecules200916566 , http://eprints.usm.my/38388/
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

A series of five new 2‐(1‐benzofuran‐2‐yl)‐2‐oxoethyl 4-(un/substituted)benzoates 4(a–e), with the general formula of C8H5O(C=O)CH2O(C=O)C6H4X, X = H, Cl, CH3, OCH3 or NO2, was synthesized in high purity and good yield under mild conditions. The synthesized products 4(a–e) were characterized by FTIR, 1H-, 13C- and 1H-13C HMQC NMR spectroscopic analysis and their 3D structures were confirmed by single-crystal X-ray diffraction studies. These compounds were screened for their antimicrobial and antioxidant activities. The tested compounds showed antimicrobial ability in the order of 4b < 4a < 4c < 4d < 4e and the highest potency with minimum inhibition concentration (MIC) value of 125 μg/mL was observed for 4e. The results of antioxidant activities revealed the highest activity for compound 4e (32.62% ± 1.34%) in diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, 4d (31.01% ± 4.35%) in ferric reducing antioxidant power (FRAP) assay and 4a (27.11% ± 1.06%) in metal chelating (MC) activity.

บรรณานุกรม :
C. S., Chidan Kumar , Li, Yee Then , Tze, Shyang Chia , Chandraju, Siddegowda , Win, Yip Foo , Sulaiman, Shaida Fariza , Hashim, Nurul Shafiqah , Kheng, Leong Ooi , Ching, Kheng Quah , Fun, Hoong Kun . (2558). Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities.
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
C. S., Chidan Kumar , Li, Yee Then , Tze, Shyang Chia , Chandraju, Siddegowda , Win, Yip Foo , Sulaiman, Shaida Fariza , Hashim, Nurul Shafiqah , Kheng, Leong Ooi , Ching, Kheng Quah , Fun, Hoong Kun . 2558. "Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities".
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
C. S., Chidan Kumar , Li, Yee Then , Tze, Shyang Chia , Chandraju, Siddegowda , Win, Yip Foo , Sulaiman, Shaida Fariza , Hashim, Nurul Shafiqah , Kheng, Leong Ooi , Ching, Kheng Quah , Fun, Hoong Kun . "Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities."
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia, 2558. Print.
C. S., Chidan Kumar , Li, Yee Then , Tze, Shyang Chia , Chandraju, Siddegowda , Win, Yip Foo , Sulaiman, Shaida Fariza , Hashim, Nurul Shafiqah , Kheng, Leong Ooi , Ching, Kheng Quah , Fun, Hoong Kun . Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities. กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia; 2558.