ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Antioxidant and Toxicity Studies of 50% Methanolic Extract of Orthosiphon stamineus Benth

หน่วยงาน Universiti Sains Malaysia, Malaysia

รายละเอียด

ชื่อเรื่อง : Antioxidant and Toxicity Studies of 50% Methanolic Extract of Orthosiphon stamineus Benth
นักวิจัย : Mun, Fei Yam , Chung, Pin Lim , Lee, Fung Ang , Lip, Yee Por , Siew, Tung Wong , Asmawi, Mohd. Zaini , Basir, Rusliza , Ahmad, Mariam
คำค้น : RS1-441 Pharmacy and materia medica
หน่วยงาน : Universiti Sains Malaysia, Malaysia
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : http://eprints.usm.my/38338/1/Antioxidant_and_Toxicity_Studies_of_50%25_Methanolic_Extract_of_Orthosiphon_stamineus_Benth.pdf , Mun, Fei Yam and Chung, Pin Lim and Lee, Fung Ang and Lip, Yee Por and Siew, Tung Wong and Asmawi, Mohd. Zaini and Basir, Rusliza and Ahmad, Mariam (2013) Antioxidant and Toxicity Studies of 50% Methanolic Extract of Orthosiphon stamineus Benth. BioMed Research International, 2013 (351602). pp. 1-10. ISSN 2314-6133
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : http://dx.doi.org/10.1155/2013/351602 , http://eprints.usm.my/38338/
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The present study evaluated the antioxidant activity and potential toxicity of 50% methanolic extract of Orthosiphon stamineus (Lamiaceae) leaves (MEOS) after acute and subchronic administration in rats. Superoxide radical scavenging, hydroxyl radical scavenging, and ferrous ion chelating methods were used to evaluate the antioxidant properties of the extract. In acute toxicity study, single dose of MEOS, 5000mg/kg, was administered to rats by oral gavage, and the treated rats were monitored for 14 days. While in the subchronic toxicity study, MEOS was administered orally, at doses of 1250, 2500, and 5000mg/kg/day for 28 days. From the results, MEOS showed good superoxide radical scavenging, hydroxyl radical scavenging, ferrous ion chelating, and antilipid peroxidation activities. There was no mortality detected or any signs of toxicity in acute and subchronic toxicity studies. Furthermore, there was no significant difference in bodyweight, relative organ weight, and haematological and biochemical parameters between bothmale and female treated rats in any doses tested.No abnormality of internal organs was observed between treatment and control groups.Theoral lethal dose determined wasmore than 5000mg/kg and the no-observed-adverse-effect level (NOAEL) of MEOS for both male and female rats is considered to be 5000mg/kg per day.

บรรณานุกรม :
Mun, Fei Yam , Chung, Pin Lim , Lee, Fung Ang , Lip, Yee Por , Siew, Tung Wong , Asmawi, Mohd. Zaini , Basir, Rusliza , Ahmad, Mariam . (2556). Antioxidant and Toxicity Studies of 50% Methanolic Extract of Orthosiphon stamineus Benth.
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
Mun, Fei Yam , Chung, Pin Lim , Lee, Fung Ang , Lip, Yee Por , Siew, Tung Wong , Asmawi, Mohd. Zaini , Basir, Rusliza , Ahmad, Mariam . 2556. "Antioxidant and Toxicity Studies of 50% Methanolic Extract of Orthosiphon stamineus Benth".
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
Mun, Fei Yam , Chung, Pin Lim , Lee, Fung Ang , Lip, Yee Por , Siew, Tung Wong , Asmawi, Mohd. Zaini , Basir, Rusliza , Ahmad, Mariam . "Antioxidant and Toxicity Studies of 50% Methanolic Extract of Orthosiphon stamineus Benth."
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia, 2556. Print.
Mun, Fei Yam , Chung, Pin Lim , Lee, Fung Ang , Lip, Yee Por , Siew, Tung Wong , Asmawi, Mohd. Zaini , Basir, Rusliza , Ahmad, Mariam . Antioxidant and Toxicity Studies of 50% Methanolic Extract of Orthosiphon stamineus Benth. กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia; 2556.