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Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats

หน่วยงาน Universiti Sains Malaysia, Malaysia

รายละเอียด

ชื่อเรื่อง : Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats
นักวิจัย : Widyawati, Tri , Yusoff, Nor Adlin , Asmawi, Mohd Zaini , Ahmad, Mariam
คำค้น : RK1-715 Dentistry , RS1-441 Pharmacy and materia medica
หน่วยงาน : Universiti Sains Malaysia, Malaysia
ผู้ร่วมงาน : -
ปีพิมพ์ : 2558
อ้างอิง : http://eprints.usm.my/38331/1/Antihyperglycemic_Effect_of_Methanol_Extract_of_Syzygium_polyanthum.pdf , Widyawati, Tri and Yusoff, Nor Adlin and Asmawi, Mohd Zaini and Ahmad, Mariam (2015) Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats. Nutrients, 7 (9). pp. 7764-7780. ISSN 2072-6643
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : https://www.ncbi.nlm.nih.gov/pubmed/26389944 , http://eprints.usm.my/38331/
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Syzygium polyanthum (S. polyanthum), a plant belonging to Myrtaceae, is widely used in Indonesian and Malaysian cuisines. Diabetic patients in Indonesia also commonly use it as a traditional medicine. Hence, this study was conducted to investigate the antihyperglycemic effect of the methanol extract (ME) of S. polyanthum leaf and its possible mechanisms of action. To test for hypoglycemic activity, ME was administered orally to normal male Sprague Dawley rats after a 12-h fast. To further test for antihyperglycemic activity, the same treatment was administered to glucose-loaded (intraperitoneal glucose tolerance test, IPGTT) and streptozotocin (STZ)-induced diabetic rats, respectively. Hypoglycemic test in normal rats did not show significant reduction in blood glucose levels (BGLs) by the extract. Furthermore, IPGTT conducted on glucose-loaded normal rats also did not show significant reduction of BGLs. However, repeated administration of metformin and three doses of ME (250, 500 and 1000 mg/kg) for six days caused significant reduction of fasting BGLs in STZ-induced diabetic rats. The possible mechanisms of action of S. polyanthum antihyperglycemic activity were assessed by measurement of intestinal glucose absorption and glucose uptake by isolated rat abdominal muscle.

บรรณานุกรม :
Widyawati, Tri , Yusoff, Nor Adlin , Asmawi, Mohd Zaini , Ahmad, Mariam . (2558). Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats.
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
Widyawati, Tri , Yusoff, Nor Adlin , Asmawi, Mohd Zaini , Ahmad, Mariam . 2558. "Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats".
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
Widyawati, Tri , Yusoff, Nor Adlin , Asmawi, Mohd Zaini , Ahmad, Mariam . "Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats."
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia, 2558. Print.
Widyawati, Tri , Yusoff, Nor Adlin , Asmawi, Mohd Zaini , Ahmad, Mariam . Antihyperglycemic Effect of Methanol Extract of Syzygium polyanthum (Wight.) Leaf in Streptozotocin-Induced Diabetic Rats. กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia; 2558.