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Phylogenetic Tree Analysis of the Cold-Hot Nature of Traditional Chinese Marine Medicine for Possible Anticancer Activity

หน่วยงาน Universiti Sains Malaysia, Malaysia

รายละเอียด

ชื่อเรื่อง : Phylogenetic Tree Analysis of the Cold-Hot Nature of Traditional Chinese Marine Medicine for Possible Anticancer Activity
นักวิจัย : Fu, Xianjun , Song, Xuxia , Li, Xuebo , Keng Wong, Keng Wong , Li, Jiaoyang , Zhang, Fengcong , Wang, Changyun , Wang, Zhenguo
คำค้น : QR180-189.5 Immunology
หน่วยงาน : Universiti Sains Malaysia, Malaysia
ผู้ร่วมงาน : -
ปีพิมพ์ : 2560
อ้างอิง : http://eprints.usm.my/37141/1/(Phylogenetic_Tree_Analysis)_4365715.pdf , Fu, Xianjun and Song, Xuxia and Li, Xuebo and Keng Wong, Keng Wong and Li, Jiaoyang and Zhang, Fengcong and Wang, Changyun and Wang, Zhenguo (2017) Phylogenetic Tree Analysis of the Cold-Hot Nature of Traditional Chinese Marine Medicine for Possible Anticancer Activity. Evidence-Based Complementary and Alternative Medicine, 2017 (436571). pp. 1-10. ISSN 1741-427X
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : https://doi.org/10.1155/2017/4365715 , http://eprints.usm.my/37141/
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Traditional Chinese Marine Medicine (TCMM) represents one of the medicinal resources for research and development of novel anticancer drugs. In this study, to investigate the presence of anticancer activity (AA) displayed by cold or hot nature of TCMM, we analyzed the association relationship and the distribution regularity of TCMMs with different nature (613 TCMMs originated from 1,091 species of marine organisms) via association rules mining and phylogenetic tree analysis. The screened association rules were collected from three taxonomy groups: (1) Bacteria superkingdom, Phaeophyceae class, Fucales order, Sargassaceae family, and Sargassum genus; (2) Viridiplantae kingdom, Streptophyta phylum, Malpighiales class, and Rhizophoraceae family; (3) Holothuroidea class, Aspidochirotida order, and Holothuria genus. Our analyses showed that TCMMs with closer taxonomic relationship weremore likely to possess anticancer bioactivity.We found that the cluster pattern ofmarine organisms with reported AA tended to cluster with cold nature TCMMs. Moreover, TCMMs with salty-cold nature demonstrated properties for softening hard mass and removing stasis to treat cancers, and species withinMetazoa orViridiplantae kingdomof cold natureweremore likely to contain AA properties.We propose that TCMMs from these marine groups may enable focused bioprospecting for discovery of novel anticancer drugs derived from marine bioresources.

บรรณานุกรม :
Fu, Xianjun , Song, Xuxia , Li, Xuebo , Keng Wong, Keng Wong , Li, Jiaoyang , Zhang, Fengcong , Wang, Changyun , Wang, Zhenguo . (2560). Phylogenetic Tree Analysis of the Cold-Hot Nature of Traditional Chinese Marine Medicine for Possible Anticancer Activity.
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
Fu, Xianjun , Song, Xuxia , Li, Xuebo , Keng Wong, Keng Wong , Li, Jiaoyang , Zhang, Fengcong , Wang, Changyun , Wang, Zhenguo . 2560. "Phylogenetic Tree Analysis of the Cold-Hot Nature of Traditional Chinese Marine Medicine for Possible Anticancer Activity".
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
Fu, Xianjun , Song, Xuxia , Li, Xuebo , Keng Wong, Keng Wong , Li, Jiaoyang , Zhang, Fengcong , Wang, Changyun , Wang, Zhenguo . "Phylogenetic Tree Analysis of the Cold-Hot Nature of Traditional Chinese Marine Medicine for Possible Anticancer Activity."
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia, 2560. Print.
Fu, Xianjun , Song, Xuxia , Li, Xuebo , Keng Wong, Keng Wong , Li, Jiaoyang , Zhang, Fengcong , Wang, Changyun , Wang, Zhenguo . Phylogenetic Tree Analysis of the Cold-Hot Nature of Traditional Chinese Marine Medicine for Possible Anticancer Activity. กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia; 2560.