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A study of high-nuclear-grade breast cancer in Thailand: Subclassification and correlation with prognostic factors and immunohistochemical study

หน่วยงาน มหาวิทยาลัยเชียงใหม่

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ชื่อเรื่อง : A study of high-nuclear-grade breast cancer in Thailand: Subclassification and correlation with prognostic factors and immunohistochemical study
นักวิจัย : Chaiwun B. , Nakrungsee S. , Sukhamwang N. , Srisukho S.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2553
อ้างอิง : 13406868 , 2-s2.0-73549107209 , 10.1007/s12282-009-0174-0 , https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73549107209&origin=inward , http://cmuir.cmu.ac.th/jspui/handle/6653943832/43372
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Objectives: To classify high-nuclear-grade breast cancer (BC) into typical medullary carcinoma (TMC), atypical medullary carcinoma (AMC), and non-medullary carcinoma (NMC), and luminal A, luminal B, and HER2, and to correlate these tumors with other prognostic factors. Materials and methods: A retrospective study reviewing high-nuclear-grade BCs. The patients' age, histologic types, various histologic features, axillary lymph node (ALN) status, and results of immunohistochemical (IHC) study were recorded and analyzed. Results: One-hundred and eighty-one cases of high-nuclear-grade BCs were reviewed and categorized into IDC, NOS (140, 77.3%), TMC (1, 0.6%), AMC (21, 11.6%), and others (19, 10.5%). The median age was younger in AMC than in NMC patients. NMC patients had a higher incidence of LVI and ALN metastasis with involvement of more than four lymph nodes (p = 0.006) whereas AMC patients had a higher mitotic index. Forty-six (35.9%) cases were triple-negative (TN), including 1 (100%), 7 (53.9%) and 38 (33.3%) cases of TMC, AMC, and NMC, respectively. AMC had a significantly lower number of node metastases (p = 0.006) than NMC; whereas TN had higher MI (p = 0.001) than non-TN. The non-TN group was subclassified into luminal A, luminal B, and HER2. Of these, TN and luminal B occurred at younger age (p = 0.01) whereas TN and luminal A had a higher mitotic count. TN had lower incidence of LNM including higher number of LNM. Conclusion: Overall, AMC-TN group showed a basal-like prognostic factor expression. NMC may be separated into TN and non-TN, with possibly different behavior. These sub-groupings should continue to be used. Interestingly, luminal A in our study tended to correlate with poor prognostic factors, thus, luminal A with high nuclear grade may not be representative of the usual luminal group profiles. © 2009 The Japanese Breast Cancer Society.

บรรณานุกรม :
Chaiwun B. , Nakrungsee S. , Sukhamwang N. , Srisukho S. . (2553). A study of high-nuclear-grade breast cancer in Thailand: Subclassification and correlation with prognostic factors and immunohistochemical study.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Chaiwun B. , Nakrungsee S. , Sukhamwang N. , Srisukho S. . 2553. "A study of high-nuclear-grade breast cancer in Thailand: Subclassification and correlation with prognostic factors and immunohistochemical study".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Chaiwun B. , Nakrungsee S. , Sukhamwang N. , Srisukho S. . "A study of high-nuclear-grade breast cancer in Thailand: Subclassification and correlation with prognostic factors and immunohistochemical study."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2553. Print.
Chaiwun B. , Nakrungsee S. , Sukhamwang N. , Srisukho S. . A study of high-nuclear-grade breast cancer in Thailand: Subclassification and correlation with prognostic factors and immunohistochemical study. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2553.