ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Pharmacokinetics and virologic response of zidovudine/lopinavir/ritonavir initiated during the third trimester of pregnancy

หน่วยงาน มหาวิทยาลัยเชียงใหม่

รายละเอียด

ชื่อเรื่อง : Pharmacokinetics and virologic response of zidovudine/lopinavir/ritonavir initiated during the third trimester of pregnancy
นักวิจัย : Cressey T. , Jourdain G. , Rawangban B. , Varadisai S. , Kongpanichkul R. , Sabsanong P. , Yuthavisuthi P. , Chirayus S. , Ngo-Giang-Huong N. , Voramongkol N. , Pattarakulwanich S. , Lallemant M.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2553
อ้างอิง : 02699370 , 2-s2.0-77956232308 , 10.1097/QAD.0b013e32833ce57d , https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77956232308&origin=inward , http://cmuir.cmu.ac.th/jspui/handle/6653943832/43234
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Objective: To evaluate the pharmacokinetics and HIV viral load response following initiation during the third trimester of pregnancy of zidovudine plus standard-dose lopinavir boosted with ritonavir (LPV/r), twice daily, until delivery for the prevention of mother-to-child transmission of HIV. Design: Prospective study nested within a multicenter, three-arm, randomized, phase III prevention of mother-to-child transmission of HIV trial in Thailand (PHPT-5, ClinicalTrials.gov Identifier: NCT00409591). Methods: Women randomized to receive 300 mg zidovudine and 400/100 mg LPV/r twice daily from 28 weeks gestation, or as soon as possible thereafter, until delivery had intensive steady-state 12-h blood sampling performed. LPV/r pharmacokinetic parameters were calculated using noncompartmental analysis. Rules were defined a priori for a LPV/r dose escalation based on the proportion of women with an LPV area under the concentration-time curve (AUC) below 52 μg h/ml (10th percentile for LPV AUC in nonpregnant adults). HIV-1 RNA response was assessed during the third trimester. Results: Thirty-eight women were evaluable; at entry, median (range) gestational age was 29 (28-36) weeks, weight 59.5 (45.0-91.6) kg, CD4 cells count 442 (260-1327) cells/μl and HIV-1 RNA viral load 7818 ( < 40-402 015) copies/ml. Geometric mean (90% confidence interval) LPV AUC, Cmax and Cmin were 64.6 (59.7-69.8) μg h/ml, 8.1 (7.5-8.7) μg/ml and 2.7 (2.4-3.0) μg/ml, respectively. Thirty-one of 38 (81%) women had an LPV AUC above the AUC target. All women had a HIV-1 viral load less than 400 copies/ml at the time of delivery. Conclusion: A short course of zidovudine plus standard-dose LPV/r initiated during the third trimester of pregnancy achieved adequate LPV exposure and virologic response. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

บรรณานุกรม :
Cressey T. , Jourdain G. , Rawangban B. , Varadisai S. , Kongpanichkul R. , Sabsanong P. , Yuthavisuthi P. , Chirayus S. , Ngo-Giang-Huong N. , Voramongkol N. , Pattarakulwanich S. , Lallemant M. . (2553). Pharmacokinetics and virologic response of zidovudine/lopinavir/ritonavir initiated during the third trimester of pregnancy.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Cressey T. , Jourdain G. , Rawangban B. , Varadisai S. , Kongpanichkul R. , Sabsanong P. , Yuthavisuthi P. , Chirayus S. , Ngo-Giang-Huong N. , Voramongkol N. , Pattarakulwanich S. , Lallemant M. . 2553. "Pharmacokinetics and virologic response of zidovudine/lopinavir/ritonavir initiated during the third trimester of pregnancy".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Cressey T. , Jourdain G. , Rawangban B. , Varadisai S. , Kongpanichkul R. , Sabsanong P. , Yuthavisuthi P. , Chirayus S. , Ngo-Giang-Huong N. , Voramongkol N. , Pattarakulwanich S. , Lallemant M. . "Pharmacokinetics and virologic response of zidovudine/lopinavir/ritonavir initiated during the third trimester of pregnancy."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2553. Print.
Cressey T. , Jourdain G. , Rawangban B. , Varadisai S. , Kongpanichkul R. , Sabsanong P. , Yuthavisuthi P. , Chirayus S. , Ngo-Giang-Huong N. , Voramongkol N. , Pattarakulwanich S. , Lallemant M. . Pharmacokinetics and virologic response of zidovudine/lopinavir/ritonavir initiated during the third trimester of pregnancy. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2553.