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Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study

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ชื่อเรื่อง : Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study
นักวิจัย : Pumthong G. , Asawanonda P. , Varothai S. , Jariyasethavong V. , Triwongwaranat D. , Suthipinittharm P. , Ingkaninan K. , Leelapornpisit P. , Waranuch N.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : 09546634 , 2-s2.0-84866295887 , 10.3109/09546634.2011.568470 , https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84866295887&origin=inward , http://cmuir.cmu.ac.th/jspui/handle/6653943832/42764
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Background: Several botanically derived agents are available for the treatment of male-pattern baldness. Objective: The aim of this study was to evaluate the efficacy of 5% hexane extract of Curcuma aeruginosa, a botanically derived inhibitor of 5a-reductase and 5% minoxidil in the treatment of androgenetic alopecia. Methods: Eighty-seven men with androgenetic alopecia (AGA) were randomized to receive 5% Curcuma aeruginosa, 5% minoxidil, combination formulation (5% hexane extract of Curcuma aeruginosa + 5% minoxidil) or placebo, twice daily for 6 months. Efficacy was assessed by target area hair count, global photographic review as well as patients' subjective assessments of hair regrowth and hair shedding. Results: There were statistically significant improvements in global photographic review (p < 0.001), subjects' overall assessments of hair regrowth (p = 0.008), and hair shedding (p = 0.004) when the combination formulation was compared with placebo. Similarly, treatment with 5% minoxidil and 5% C. aeruginosa extract also led to some degrees of hair regrowth. There were no serious adverse events during and after the study. Conclusion: In men with hair loss in the vertex area of the scalp, the combination of 5% hexane extract of C. aeruginosa and 5% minoxidil slowed hair loss and increased hair growth. © 2012 Informa Healthcare USA on behalf of Informa UK Ltd.

บรรณานุกรม :
Pumthong G. , Asawanonda P. , Varothai S. , Jariyasethavong V. , Triwongwaranat D. , Suthipinittharm P. , Ingkaninan K. , Leelapornpisit P. , Waranuch N. . (2555). Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Pumthong G. , Asawanonda P. , Varothai S. , Jariyasethavong V. , Triwongwaranat D. , Suthipinittharm P. , Ingkaninan K. , Leelapornpisit P. , Waranuch N. . 2555. "Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Pumthong G. , Asawanonda P. , Varothai S. , Jariyasethavong V. , Triwongwaranat D. , Suthipinittharm P. , Ingkaninan K. , Leelapornpisit P. , Waranuch N. . "Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2555. Print.
Pumthong G. , Asawanonda P. , Varothai S. , Jariyasethavong V. , Triwongwaranat D. , Suthipinittharm P. , Ingkaninan K. , Leelapornpisit P. , Waranuch N. . Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2555.