ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Uptake of Early infant diagnosis in Thailand's national program for preventing mother-to-child HIV transmission and linkage to care, 2008-2011

หน่วยงาน มหาวิทยาลัยเชียงใหม่

รายละเอียด

ชื่อเรื่อง : Uptake of Early infant diagnosis in Thailand's national program for preventing mother-to-child HIV transmission and linkage to care, 2008-2011
นักวิจัย : Naiwatanakul T. , Voramongkol N. , Punsuwan N. , Lolekha R. , Gass R. , Thaisri H. , Leechanachai P. , Wolfe M. , Boonsuk S. , Bhakeecheep S.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2559
อ้างอิง : 2-s2.0-84961792843 , 10.7448/IAS.19.1.20511 , https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84961792843&origin=inward , http://cmuir.cmu.ac.th/jspui/handle/6653943832/42026
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

© 2016 Cui Y et al; licensee International AIDS Society. Introduction: Early infant diagnosis (EID) has been a component of Thailand's prevention of mother-to-child HIV transmission (PMTCT) programme since 2007. This study assessed the uptake, EID coverage, proportion of HIV-exposed infants receiving a definitive HIV diagnosis, mother-to-child transmission (MTCT) rates and linkage to HIV care and treatment. Methods: Infant polymerase chain reaction (PCR) testing data from the National AIDS Program database were analyzed. EID coverage was calculated as the percentage of number of HIV-exposed infants receiving > 1 HIV PCR test divided by the number of HIV-exposed infants estimated from HIV prevalence and live-birth registry data. Definitive HIV diagnosis was defined as having two concordant PCR results. MTCT rates were calculated based on infants tested with PCR and applied as a best-case scenario, and a sensitivity analysis was used to adjust these rates in average and worst scenarios. We defined linkage to HIV care as infants with at least one PCR-positive test who were registered with Thailand's National AIDS Program. Chi-squared tests for linear trend were used to analyze changes in programme coverage. Results: For 2008 to 2011, the average EID coverage rate increased from 54 to 76% (p < 0.001), with 65% coverage (13,761/21,099) overall. The number of hospitals submitting EID samples increased from 458 to 645, and the percentage of community hospitals submitting samples increased from 75 to 78% (p = 0.044). A definitive HIV diagnosis was made for 10,854 (79%) infants during this period. The adjusted MTCT rates had significantly decreasing trends in all scenarios. Overall, an estimated 53% (429/804) of HIV-infected infants were identified through the EID programme, and 80% (341/429) of infants testing positive were linked to care. The overall rate of antiretroviral treatment (ART) initiation within one year of age was 37% (157/429), with an increasing trend from 28 to 52% (p < 0.001). Conclusions: EID coverage increased and MTCT rates decreased during 2008 to 2011; however, about half of HIV-infected infants still did not receive EID. Most HIV-infected infants were linked to care but less than half initiated ART within one year of age. Active follow-up of HIV-exposed infants to increase early detection of HIV infection and early initiation of ART should be more widely implemented.

บรรณานุกรม :
Naiwatanakul T. , Voramongkol N. , Punsuwan N. , Lolekha R. , Gass R. , Thaisri H. , Leechanachai P. , Wolfe M. , Boonsuk S. , Bhakeecheep S. . (2559). Uptake of Early infant diagnosis in Thailand's national program for preventing mother-to-child HIV transmission and linkage to care, 2008-2011.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Naiwatanakul T. , Voramongkol N. , Punsuwan N. , Lolekha R. , Gass R. , Thaisri H. , Leechanachai P. , Wolfe M. , Boonsuk S. , Bhakeecheep S. . 2559. "Uptake of Early infant diagnosis in Thailand's national program for preventing mother-to-child HIV transmission and linkage to care, 2008-2011".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Naiwatanakul T. , Voramongkol N. , Punsuwan N. , Lolekha R. , Gass R. , Thaisri H. , Leechanachai P. , Wolfe M. , Boonsuk S. , Bhakeecheep S. . "Uptake of Early infant diagnosis in Thailand's national program for preventing mother-to-child HIV transmission and linkage to care, 2008-2011."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2559. Print.
Naiwatanakul T. , Voramongkol N. , Punsuwan N. , Lolekha R. , Gass R. , Thaisri H. , Leechanachai P. , Wolfe M. , Boonsuk S. , Bhakeecheep S. . Uptake of Early infant diagnosis in Thailand's national program for preventing mother-to-child HIV transmission and linkage to care, 2008-2011. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2559.