ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Clinical characteristics and long-term outcomes of warm-type autoimmune hemolytic anemia

หน่วยงาน มหาวิทยาลัยเชียงใหม่

รายละเอียด

ชื่อเรื่อง : Clinical characteristics and long-term outcomes of warm-type autoimmune hemolytic anemia
นักวิจัย : Rattarittamrong E. , Eiamprapai P. , Tantiworawit A. , Rattanathammethee T. , Hantrakool S. , Chai-Adisaksopha C. , Norasetthada L.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2559
อ้างอิง : 10245332 , 2-s2.0-84978493510 , 10.1080/10245332.2016.1138621 , https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84978493510&origin=inward , http://cmuir.cmu.ac.th/jspui/handle/6653943832/41730
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

© 2016 Informa UK Limited, trading as Taylor & Francis Group. Objectives: To study the clinical manifestations, outcomes, and survival of warm-type autoimmune hemolytic anemia (AIHA) patients. Methods: This study was a retrospective single-center study from 2002 to 2013. Clinical data of AIHA patients were reviewed and analyzed. Results: One hundred and one patients were included, of whom 77% were female with a median age of 43 years. Primary AIHA was found in 61% of the patients. The secondary causes were systemic lupus erythematosus (SLE) (64%), solid malignancies (13%), lymphomas (10%), drugs (8%), and infections (5%). Most patients (96%) responded to steroids, which were not different between primary and secondary AIHA. Second-line treatments were required in 33 patients (33%). The indications were steroid dependence (58%), relapse (30%), and others (12%). The most common second-line treatment was cyclophosphamide (52%). The response rate for second-line treatments was 93%. Relapse occurred in 50 patients (50%) in which 58% occurred more than 3 years after diagnosis. The SLE patients relapsed and received second-line therapy more than the non-SLE group (P < 0.001). At the median 53-month follow-up, the overall survival (OS) was 84%. The independent risk factors for OS were age more than 50 years and malignancy. Sepsis was the most common cause of death. Discussion and conclusion: AIHA has a good prognosis and long-term survival especially in young patients without malignancy. Most patients have responded initially to steroids and have a high response rate to second-line therapy. Carefully adjusted and rapid taper of immunosuppressant is necessary to avoid sepsis complications.

บรรณานุกรม :
Rattarittamrong E. , Eiamprapai P. , Tantiworawit A. , Rattanathammethee T. , Hantrakool S. , Chai-Adisaksopha C. , Norasetthada L. . (2559). Clinical characteristics and long-term outcomes of warm-type autoimmune hemolytic anemia.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Rattarittamrong E. , Eiamprapai P. , Tantiworawit A. , Rattanathammethee T. , Hantrakool S. , Chai-Adisaksopha C. , Norasetthada L. . 2559. "Clinical characteristics and long-term outcomes of warm-type autoimmune hemolytic anemia".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Rattarittamrong E. , Eiamprapai P. , Tantiworawit A. , Rattanathammethee T. , Hantrakool S. , Chai-Adisaksopha C. , Norasetthada L. . "Clinical characteristics and long-term outcomes of warm-type autoimmune hemolytic anemia."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2559. Print.
Rattarittamrong E. , Eiamprapai P. , Tantiworawit A. , Rattanathammethee T. , Hantrakool S. , Chai-Adisaksopha C. , Norasetthada L. . Clinical characteristics and long-term outcomes of warm-type autoimmune hemolytic anemia. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2559.