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Incidence and predictors of interstitial lung disease (ILD) in Thai patients with early systemic sclerosis: Inception cohort study

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ชื่อเรื่อง : Incidence and predictors of interstitial lung disease (ILD) in Thai patients with early systemic sclerosis: Inception cohort study
นักวิจัย : Wangkaew S. , Euathrongchit J. , Wattanawittawas P. , Kasitanon N. , Louthrenoo W.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2559
อ้างอิง : 14397595 , 2-s2.0-84951283390 , 10.3109/14397595.2015.1115455 , https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84951283390&origin=inward , http://cmuir.cmu.ac.th/jspui/handle/6653943832/41722
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

© 2015 Japan College of Rheumatology. Objectives: To determine and compare the prevalence of interstitial lung disease (ILD), the severity of high-resolution computed tomography (HRCT) score and incidence rate (IR) of ILD between the two subsets of early-SSc (systemic sclerosis) patients. We also determined the factors associated with ILD. Methods: We used an inception cohort of early-SSc patients seen between January 2010 and June 2014. All patients underwent HRCT at study entry and annually thereafter. Results: One hundred and thirteen patients (66 females and 89 diffuse cutaneous SSc [dcSSc]) with a mean ± SD age of 53.4 ± 8.4 years and mean disease duration of 12.9 ± 10.3 months at cohort entry were enrolled. At enrollment, patients with dcSSc had a higher prevalence of ILD (78.7% vs. 45.8%, p = 0.002), and a higher total HRCT score (10.3 ± 9.5 vs. 4.4 ± 5.6, p = 0.001) compared with limited cutaneous SSc (lcSSc). DcSSc patients had a higher IR of ILD than lcSSc patients (58.8 vs.17.3 per 100 person-years, p < 0.001). Univariable analysis revealed that male gender, presence of anti-Scl 70 and absent anti-centromere antibody was significant predictors of ILD. In Cox-regression analysis, a positive anti-centromere [hazard ratio (HR) 0.09 95% confidence interval (95% CI 0.01–0.73)] was a protective factor. Conclusions: DcSSc patients had more severe HRCT scores and higher IR of ILD compared with lcSSc patients. Male gender, presence of anti-Scl 70, and absent anti-centromere antibody predicted the future development of ILD in early-SSc patients.

บรรณานุกรม :
Wangkaew S. , Euathrongchit J. , Wattanawittawas P. , Kasitanon N. , Louthrenoo W. . (2559). Incidence and predictors of interstitial lung disease (ILD) in Thai patients with early systemic sclerosis: Inception cohort study.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Wangkaew S. , Euathrongchit J. , Wattanawittawas P. , Kasitanon N. , Louthrenoo W. . 2559. "Incidence and predictors of interstitial lung disease (ILD) in Thai patients with early systemic sclerosis: Inception cohort study".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Wangkaew S. , Euathrongchit J. , Wattanawittawas P. , Kasitanon N. , Louthrenoo W. . "Incidence and predictors of interstitial lung disease (ILD) in Thai patients with early systemic sclerosis: Inception cohort study."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2559. Print.
Wangkaew S. , Euathrongchit J. , Wattanawittawas P. , Kasitanon N. , Louthrenoo W. . Incidence and predictors of interstitial lung disease (ILD) in Thai patients with early systemic sclerosis: Inception cohort study. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2559.