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Is non-HDL-cholesterol a better predictor of long-term outcome in patients after acute myocardial infarction compared to LDL-cholesterol?: A retrospective study

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ชื่อเรื่อง : Is non-HDL-cholesterol a better predictor of long-term outcome in patients after acute myocardial infarction compared to LDL-cholesterol?: A retrospective study
นักวิจัย : Wongcharoen W. , Sutthiwutthichai S. , Gunaparn S. , Phrommintikul A.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2560
อ้างอิง : 2-s2.0-85008319864 , 10.1186/s12872-016-0450-9 , https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85008319864&origin=inward , http://cmuir.cmu.ac.th/jspui/handle/6653943832/40841
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

© 2017 The Author(s). Background: It has recently been shown that non-high density lipoprotein cholesterol (non-HDL-C) may be a better predictor of cardiovascular risk than low density lipoprotein cholesterol (LDL-C). Based on known ethic differences in lipid parameters and cardiovascular risk prediction, we sought to study the predictability of attaining non-HDL-C target and long-term major adverse cardiovascular event (MACE) in Thai patients after acute myocardial infarction (AMI) compared to attaining LDL-C target. Methods: We retrospectively obtained the data of all patients who were admitted at Maharaj Nakorn Chiang Mai hospital due to AMI during 2006-2013. The mean non-HDL-C and LDL-C during long-term follow-up were used to predict MACE at each time point. The patients were classified as target attainment if non-HDL-C < 100 mg/dl and/or LDL-C < 70 mg/dl. The MACE was defined as combination of all-cause death, nonfatal coronary event and nonfatal stroke. Results: During mean follow-up of 2.6 ± 1.6 years among 868 patients after AMI, 34.4% achieved non-HDL-C target, 23.7% achieved LDL-C target and 21.2% experienced MACEs. LDL-C and non-HDL-C were directly compared in Cox regression model. Compared with non-HDL-C < 100 mg/dl, patients with non-HDL-C of > 130 mg/dl had higher incidence of MACEs (HR 3.15, 95% CI 1.46-6.80, P = 0.003). Surprisingly, LDL-C > 100 mg/dl was associated with reduced risk of MACE as compared to LDL < 70 mg/dl (HR 0.42, 95% CI 0.18-0.98, p = 0.046) after direct pairwise comparison with non-HDL-C level. Conclusions: Non-attaining non-HDL-C goal predicted MACE at long-term follow-up after AMI whereas non-attaining LDL-C goal was not associated with the higher risk. Therefore, non-HDL-C may be a more suitable target of dyslipidemia treatment than LDL-C in patients after AMI.

บรรณานุกรม :
Wongcharoen W. , Sutthiwutthichai S. , Gunaparn S. , Phrommintikul A. . (2560). Is non-HDL-cholesterol a better predictor of long-term outcome in patients after acute myocardial infarction compared to LDL-cholesterol?: A retrospective study.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Wongcharoen W. , Sutthiwutthichai S. , Gunaparn S. , Phrommintikul A. . 2560. "Is non-HDL-cholesterol a better predictor of long-term outcome in patients after acute myocardial infarction compared to LDL-cholesterol?: A retrospective study".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Wongcharoen W. , Sutthiwutthichai S. , Gunaparn S. , Phrommintikul A. . "Is non-HDL-cholesterol a better predictor of long-term outcome in patients after acute myocardial infarction compared to LDL-cholesterol?: A retrospective study."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2560. Print.
Wongcharoen W. , Sutthiwutthichai S. , Gunaparn S. , Phrommintikul A. . Is non-HDL-cholesterol a better predictor of long-term outcome in patients after acute myocardial infarction compared to LDL-cholesterol?: A retrospective study. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2560.