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Overview of Antagonists Used for Determining the Mechanisms of Action Employed by Potential Vasodilators with Their Suggested Signaling Pathways

หน่วยงาน Universiti Sains Malaysia, Malaysia

รายละเอียด

ชื่อเรื่อง : Overview of Antagonists Used for Determining the Mechanisms of Action Employed by Potential Vasodilators with Their Suggested Signaling Pathways
นักวิจัย : Mun, Fei Yam , Asmawi, Mohd Zaini , Yean, Chun Loh , Chu, Shan Tan , Yung, Sing Ch’ng , Ahmad, Mariam
คำค้น : RS1-441 Pharmacy and materia medica
หน่วยงาน : Universiti Sains Malaysia, Malaysia
ผู้ร่วมงาน : -
ปีพิมพ์ : 2559
อ้างอิง : Yean, Chun Loh and Chu, Shan Tan and Yung, Sing Ch’ng and Ahmad, Mariam and Asmawi, Mohd Zaini and Mun, Fei Yam (2016) Overview of Antagonists Used for Determining the Mechanisms of Action Employed by Potential Vasodilators with Their Suggested Signaling Pathways. Molecules, 21 (4). pp. 1-34. ISSN 1420-3049 , http://eprints.usm.my/37103/1/(Overview_of_Antagonists_Used)_molecules%2D21%2D00495.pdf
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : https://doi.org/10.2147/IMCRJ.S124524 , http://eprints.usm.my/37103/
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

This paper is a review on the types of antagonists and the signaling mechanism pathways that have been used to determine the mechanisms of action employed for vasodilation by test compounds. Thus, we exhaustively reviewed and analyzed reports related to this topic published in PubMed between the years of 2010 till 2015. The aim of this paperis to suggest the most appropriate type of antagonists that correspond to receptors that would be involved during the mechanistic studies, as well as the latest signaling pathways trends that are being studied in order to determine the route(s) that atest compound employs for inducing vasodilation. The methods to perform the mechanism studies were included. Fundamentally, the affinity, specificity and selectivity of the antagonists to their receptors or enzymes were clearly elaborated as well as the solubility and reversibility. All the signaling pathways on the mechanisms of action involved in the vascular tone regulation have been well described in previous review articles. However, the most appropriate antagonists that should be utilized have never been suggested and elaborated before, hence the reason for this review.

บรรณานุกรม :
Mun, Fei Yam , Asmawi, Mohd Zaini , Yean, Chun Loh , Chu, Shan Tan , Yung, Sing Ch’ng , Ahmad, Mariam . (2559). Overview of Antagonists Used for Determining the Mechanisms of Action Employed by Potential Vasodilators with Their Suggested Signaling Pathways.
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
Mun, Fei Yam , Asmawi, Mohd Zaini , Yean, Chun Loh , Chu, Shan Tan , Yung, Sing Ch’ng , Ahmad, Mariam . 2559. "Overview of Antagonists Used for Determining the Mechanisms of Action Employed by Potential Vasodilators with Their Suggested Signaling Pathways".
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
Mun, Fei Yam , Asmawi, Mohd Zaini , Yean, Chun Loh , Chu, Shan Tan , Yung, Sing Ch’ng , Ahmad, Mariam . "Overview of Antagonists Used for Determining the Mechanisms of Action Employed by Potential Vasodilators with Their Suggested Signaling Pathways."
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia, 2559. Print.
Mun, Fei Yam , Asmawi, Mohd Zaini , Yean, Chun Loh , Chu, Shan Tan , Yung, Sing Ch’ng , Ahmad, Mariam . Overview of Antagonists Used for Determining the Mechanisms of Action Employed by Potential Vasodilators with Their Suggested Signaling Pathways. กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia; 2559.