ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study

หน่วยงาน มหาวิทยาลัยเชียงใหม่

รายละเอียด

ชื่อเรื่อง : Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study
นักวิจัย : Gattermann,N. , Finelli,C. , Della Porta,M. , Fénaux,P. , Ganser,A.G. , Guerci-Bresler,A. , Schmid,M.L. , Taylor,K.M. , Vassilieff,D. , Habr,D. , Domokos,G. , Roubert,B. , Rose,C.S. , Aǧaoǧlu,L. , Alimena,G. , Alonso,D. , Amé,S. , Angelucci,E. , Arrizabalaga,B. , Athanasiou-Metaxa,M. , Augustson,B.M. , Aydınok,Y. , Baba,A.A. , Baccarani,M. , Beck,J.T. , Béris,P.H. , Beyne-Rauzy,O. , Birgens,H.S. , B́ordessoule,D. , Borgna-Pignatti,C. , Bosly,A.E. , Bouabdallah,K. , Bowden,D.K. , Bowen,D.T. , Bron,D.G. , Cappellini,M.D.O. , Capra,M.E.Z. , Cartron,G. , Cazzola,M. , Chalkias,C. , Chan,L. , Chancharunee,S. , Chapman,C.S. , Charoenkwan,P. , Chasapopoulou,E. , Chèze,S. , Chuansumrit,A. , Cianciulli,P. , Dauriac,C. , Delforge,M. , Dölken,G. , Dombret,H. , Duyster,J. , Economopoulos,T.H. , Ehninger,G.E. , Elalfy,M.S. , El Beshlawy,A. , Enggaard,L. , Fillet,G. , Filosa,A. , Forni,G.L. , Galanello,R. , Gastl,G.A. , Giraudier,S. , Goldfarb,A.W. , Grigg,A.P. , Gümrük,F.U. , Ha,S.Y. , Haase,D. , Heinrich,B. , Hertzberg,M.S. , Ho,J. , Hsu,H. , Huang,S. , Hunault-Berger,M. , Inusa,B.P.D. , Jaulmes,D. , Jensen,J.M. , Kattamis,A.C. , Kilinç,Y. , Kim,K. , Kinsey,S.E. , Kjeldsen,L. , Koren,A. , Lai,M. , Lai,Y. , Lee,J. , Lee,K. , Lee,S. , Legros,L. , Li,C. , Li,C. , Li,Q. , Lin,K. , Linkesch,W.M. , Lübbert,M. , Lutz,D. , Mohamed Thalha,A.J. , Mufti,G.J. , Muus,P.K. , Nobile,F. , Papadopoulos,N.T. , Perrotta,S. , Petrini,M.T. , Pfeilstöcker,M. , Piga,A.M. , Poole,J.E. , Porter,J.B. , Pungolino,E.M. , Quarta,G. , Ravoet,C. , Jolimont Lobbes,H.H. , Remacha,A.F. , Roy,L. , Saglio,G.G. , Sanz,G.F. , Schmugge,M. , Schots,H. , Secchi,G. , Seymour,J.F. , Shah,F.T. , Shah,H.N. , Shen,Z. , Slama,B. , Sutcharitchan,P. , Taher,A.T. , Tamary,H. , Tesch,H.J. , Thein,S.L. , Troncy,J. , Villegas,A.M. , Viprakasit,V. , Wainwright,L. , Waßmann,B. , Wettervald,M. , Will,A.M. , Wörmann,B.J. , Wright,J.G. , Yeh,S. , Yoon,S. , Zoumbos,N.C. , Zweegman,S.
คำค้น : Cancer Research , Hematology , Oncology
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2553
อ้างอิง : 01452126 , 2-s2.0-77955268192 , 10.1016/j.leukres.2010.03.009 , 20451251 , http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955268192&origin=inward , http://cmuir.cmu.ac.th/handle/6653943832/38178
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The prospective 1-year EPIC study enrolled 341 patients with myelodysplastic syndromes (MDS); although baseline iron burden was >2500. ng/mL, ∼50% were chelation-naïve. Overall median serum ferritin decreased significantly at 1 year (p=0.002). Decreases occurred irrespective of whether patients were chelation-naïve or previously chelated; changes were dependent on dose adjustments and ongoing iron intake. Sustained reductions in labile plasma iron were observed. Discontinuation rate (48.7%) and adverse event profile were consistent with previously reported deferasirox data in MDS. Alanine aminotransferase levels decreased significantly; change correlated significantly with reduction in serum ferritin (p<0.0001). This large dataset prospectively confirms the efficacy and well characterizes the safety profile of deferasirox in MDS. © 2010 Elsevier Ltd.

บรรณานุกรม :
Gattermann,N. , Finelli,C. , Della Porta,M. , Fénaux,P. , Ganser,A.G. , Guerci-Bresler,A. , Schmid,M.L. , Taylor,K.M. , Vassilieff,D. , Habr,D. , Domokos,G. , Roubert,B. , Rose,C.S. , Aǧaoǧlu,L. , Alimena,G. , Alonso,D. , Amé,S. , Angelucci,E. , Arrizabalaga,B. , Athanasiou-Metaxa,M. , Augustson,B.M. , Aydınok,Y. , Baba,A.A. , Baccarani,M. , Beck,J.T. , Béris,P.H. , Beyne-Rauzy,O. , Birgens,H.S. , B́ordessoule,D. , Borgna-Pignatti,C. , Bosly,A.E. , Bouabdallah,K. , Bowden,D.K. , Bowen,D.T. , Bron,D.G. , Cappellini,M.D.O. , Capra,M.E.Z. , Cartron,G. , Cazzola,M. , Chalkias,C. , Chan,L. , Chancharunee,S. , Chapman,C.S. , Charoenkwan,P. , Chasapopoulou,E. , Chèze,S. , Chuansumrit,A. , Cianciulli,P. , Dauriac,C. , Delforge,M. , Dölken,G. , Dombret,H. , Duyster,J. , Economopoulos,T.H. , Ehninger,G.E. , Elalfy,M.S. , El Beshlawy,A. , Enggaard,L. , Fillet,G. , Filosa,A. , Forni,G.L. , Galanello,R. , Gastl,G.A. , Giraudier,S. , Goldfarb,A.W. , Grigg,A.P. , Gümrük,F.U. , Ha,S.Y. , Haase,D. , Heinrich,B. , Hertzberg,M.S. , Ho,J. , Hsu,H. , Huang,S. , Hunault-Berger,M. , Inusa,B.P.D. , Jaulmes,D. , Jensen,J.M. , Kattamis,A.C. , Kilinç,Y. , Kim,K. , Kinsey,S.E. , Kjeldsen,L. , Koren,A. , Lai,M. , Lai,Y. , Lee,J. , Lee,K. , Lee,S. , Legros,L. , Li,C. , Li,C. , Li,Q. , Lin,K. , Linkesch,W.M. , Lübbert,M. , Lutz,D. , Mohamed Thalha,A.J. , Mufti,G.J. , Muus,P.K. , Nobile,F. , Papadopoulos,N.T. , Perrotta,S. , Petrini,M.T. , Pfeilstöcker,M. , Piga,A.M. , Poole,J.E. , Porter,J.B. , Pungolino,E.M. , Quarta,G. , Ravoet,C. , Jolimont Lobbes,H.H. , Remacha,A.F. , Roy,L. , Saglio,G.G. , Sanz,G.F. , Schmugge,M. , Schots,H. , Secchi,G. , Seymour,J.F. , Shah,F.T. , Shah,H.N. , Shen,Z. , Slama,B. , Sutcharitchan,P. , Taher,A.T. , Tamary,H. , Tesch,H.J. , Thein,S.L. , Troncy,J. , Villegas,A.M. , Viprakasit,V. , Wainwright,L. , Waßmann,B. , Wettervald,M. , Will,A.M. , Wörmann,B.J. , Wright,J.G. , Yeh,S. , Yoon,S. , Zoumbos,N.C. , Zweegman,S. . (2553). Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Gattermann,N. , Finelli,C. , Della Porta,M. , Fénaux,P. , Ganser,A.G. , Guerci-Bresler,A. , Schmid,M.L. , Taylor,K.M. , Vassilieff,D. , Habr,D. , Domokos,G. , Roubert,B. , Rose,C.S. , Aǧaoǧlu,L. , Alimena,G. , Alonso,D. , Amé,S. , Angelucci,E. , Arrizabalaga,B. , Athanasiou-Metaxa,M. , Augustson,B.M. , Aydınok,Y. , Baba,A.A. , Baccarani,M. , Beck,J.T. , Béris,P.H. , Beyne-Rauzy,O. , Birgens,H.S. , B́ordessoule,D. , Borgna-Pignatti,C. , Bosly,A.E. , Bouabdallah,K. , Bowden,D.K. , Bowen,D.T. , Bron,D.G. , Cappellini,M.D.O. , Capra,M.E.Z. , Cartron,G. , Cazzola,M. , Chalkias,C. , Chan,L. , Chancharunee,S. , Chapman,C.S. , Charoenkwan,P. , Chasapopoulou,E. , Chèze,S. , Chuansumrit,A. , Cianciulli,P. , Dauriac,C. , Delforge,M. , Dölken,G. , Dombret,H. , Duyster,J. , Economopoulos,T.H. , Ehninger,G.E. , Elalfy,M.S. , El Beshlawy,A. , Enggaard,L. , Fillet,G. , Filosa,A. , Forni,G.L. , Galanello,R. , Gastl,G.A. , Giraudier,S. , Goldfarb,A.W. , Grigg,A.P. , Gümrük,F.U. , Ha,S.Y. , Haase,D. , Heinrich,B. , Hertzberg,M.S. , Ho,J. , Hsu,H. , Huang,S. , Hunault-Berger,M. , Inusa,B.P.D. , Jaulmes,D. , Jensen,J.M. , Kattamis,A.C. , Kilinç,Y. , Kim,K. , Kinsey,S.E. , Kjeldsen,L. , Koren,A. , Lai,M. , Lai,Y. , Lee,J. , Lee,K. , Lee,S. , Legros,L. , Li,C. , Li,C. , Li,Q. , Lin,K. , Linkesch,W.M. , Lübbert,M. , Lutz,D. , Mohamed Thalha,A.J. , Mufti,G.J. , Muus,P.K. , Nobile,F. , Papadopoulos,N.T. , Perrotta,S. , Petrini,M.T. , Pfeilstöcker,M. , Piga,A.M. , Poole,J.E. , Porter,J.B. , Pungolino,E.M. , Quarta,G. , Ravoet,C. , Jolimont Lobbes,H.H. , Remacha,A.F. , Roy,L. , Saglio,G.G. , Sanz,G.F. , Schmugge,M. , Schots,H. , Secchi,G. , Seymour,J.F. , Shah,F.T. , Shah,H.N. , Shen,Z. , Slama,B. , Sutcharitchan,P. , Taher,A.T. , Tamary,H. , Tesch,H.J. , Thein,S.L. , Troncy,J. , Villegas,A.M. , Viprakasit,V. , Wainwright,L. , Waßmann,B. , Wettervald,M. , Will,A.M. , Wörmann,B.J. , Wright,J.G. , Yeh,S. , Yoon,S. , Zoumbos,N.C. , Zweegman,S. . 2553. "Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Gattermann,N. , Finelli,C. , Della Porta,M. , Fénaux,P. , Ganser,A.G. , Guerci-Bresler,A. , Schmid,M.L. , Taylor,K.M. , Vassilieff,D. , Habr,D. , Domokos,G. , Roubert,B. , Rose,C.S. , Aǧaoǧlu,L. , Alimena,G. , Alonso,D. , Amé,S. , Angelucci,E. , Arrizabalaga,B. , Athanasiou-Metaxa,M. , Augustson,B.M. , Aydınok,Y. , Baba,A.A. , Baccarani,M. , Beck,J.T. , Béris,P.H. , Beyne-Rauzy,O. , Birgens,H.S. , B́ordessoule,D. , Borgna-Pignatti,C. , Bosly,A.E. , Bouabdallah,K. , Bowden,D.K. , Bowen,D.T. , Bron,D.G. , Cappellini,M.D.O. , Capra,M.E.Z. , Cartron,G. , Cazzola,M. , Chalkias,C. , Chan,L. , Chancharunee,S. , Chapman,C.S. , Charoenkwan,P. , Chasapopoulou,E. , Chèze,S. , Chuansumrit,A. , Cianciulli,P. , Dauriac,C. , Delforge,M. , Dölken,G. , Dombret,H. , Duyster,J. , Economopoulos,T.H. , Ehninger,G.E. , Elalfy,M.S. , El Beshlawy,A. , Enggaard,L. , Fillet,G. , Filosa,A. , Forni,G.L. , Galanello,R. , Gastl,G.A. , Giraudier,S. , Goldfarb,A.W. , Grigg,A.P. , Gümrük,F.U. , Ha,S.Y. , Haase,D. , Heinrich,B. , Hertzberg,M.S. , Ho,J. , Hsu,H. , Huang,S. , Hunault-Berger,M. , Inusa,B.P.D. , Jaulmes,D. , Jensen,J.M. , Kattamis,A.C. , Kilinç,Y. , Kim,K. , Kinsey,S.E. , Kjeldsen,L. , Koren,A. , Lai,M. , Lai,Y. , Lee,J. , Lee,K. , Lee,S. , Legros,L. , Li,C. , Li,C. , Li,Q. , Lin,K. , Linkesch,W.M. , Lübbert,M. , Lutz,D. , Mohamed Thalha,A.J. , Mufti,G.J. , Muus,P.K. , Nobile,F. , Papadopoulos,N.T. , Perrotta,S. , Petrini,M.T. , Pfeilstöcker,M. , Piga,A.M. , Poole,J.E. , Porter,J.B. , Pungolino,E.M. , Quarta,G. , Ravoet,C. , Jolimont Lobbes,H.H. , Remacha,A.F. , Roy,L. , Saglio,G.G. , Sanz,G.F. , Schmugge,M. , Schots,H. , Secchi,G. , Seymour,J.F. , Shah,F.T. , Shah,H.N. , Shen,Z. , Slama,B. , Sutcharitchan,P. , Taher,A.T. , Tamary,H. , Tesch,H.J. , Thein,S.L. , Troncy,J. , Villegas,A.M. , Viprakasit,V. , Wainwright,L. , Waßmann,B. , Wettervald,M. , Will,A.M. , Wörmann,B.J. , Wright,J.G. , Yeh,S. , Yoon,S. , Zoumbos,N.C. , Zweegman,S. . "Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2553. Print.
Gattermann,N. , Finelli,C. , Della Porta,M. , Fénaux,P. , Ganser,A.G. , Guerci-Bresler,A. , Schmid,M.L. , Taylor,K.M. , Vassilieff,D. , Habr,D. , Domokos,G. , Roubert,B. , Rose,C.S. , Aǧaoǧlu,L. , Alimena,G. , Alonso,D. , Amé,S. , Angelucci,E. , Arrizabalaga,B. , Athanasiou-Metaxa,M. , Augustson,B.M. , Aydınok,Y. , Baba,A.A. , Baccarani,M. , Beck,J.T. , Béris,P.H. , Beyne-Rauzy,O. , Birgens,H.S. , B́ordessoule,D. , Borgna-Pignatti,C. , Bosly,A.E. , Bouabdallah,K. , Bowden,D.K. , Bowen,D.T. , Bron,D.G. , Cappellini,M.D.O. , Capra,M.E.Z. , Cartron,G. , Cazzola,M. , Chalkias,C. , Chan,L. , Chancharunee,S. , Chapman,C.S. , Charoenkwan,P. , Chasapopoulou,E. , Chèze,S. , Chuansumrit,A. , Cianciulli,P. , Dauriac,C. , Delforge,M. , Dölken,G. , Dombret,H. , Duyster,J. , Economopoulos,T.H. , Ehninger,G.E. , Elalfy,M.S. , El Beshlawy,A. , Enggaard,L. , Fillet,G. , Filosa,A. , Forni,G.L. , Galanello,R. , Gastl,G.A. , Giraudier,S. , Goldfarb,A.W. , Grigg,A.P. , Gümrük,F.U. , Ha,S.Y. , Haase,D. , Heinrich,B. , Hertzberg,M.S. , Ho,J. , Hsu,H. , Huang,S. , Hunault-Berger,M. , Inusa,B.P.D. , Jaulmes,D. , Jensen,J.M. , Kattamis,A.C. , Kilinç,Y. , Kim,K. , Kinsey,S.E. , Kjeldsen,L. , Koren,A. , Lai,M. , Lai,Y. , Lee,J. , Lee,K. , Lee,S. , Legros,L. , Li,C. , Li,C. , Li,Q. , Lin,K. , Linkesch,W.M. , Lübbert,M. , Lutz,D. , Mohamed Thalha,A.J. , Mufti,G.J. , Muus,P.K. , Nobile,F. , Papadopoulos,N.T. , Perrotta,S. , Petrini,M.T. , Pfeilstöcker,M. , Piga,A.M. , Poole,J.E. , Porter,J.B. , Pungolino,E.M. , Quarta,G. , Ravoet,C. , Jolimont Lobbes,H.H. , Remacha,A.F. , Roy,L. , Saglio,G.G. , Sanz,G.F. , Schmugge,M. , Schots,H. , Secchi,G. , Seymour,J.F. , Shah,F.T. , Shah,H.N. , Shen,Z. , Slama,B. , Sutcharitchan,P. , Taher,A.T. , Tamary,H. , Tesch,H.J. , Thein,S.L. , Troncy,J. , Villegas,A.M. , Viprakasit,V. , Wainwright,L. , Waßmann,B. , Wettervald,M. , Will,A.M. , Wörmann,B.J. , Wright,J.G. , Yeh,S. , Yoon,S. , Zoumbos,N.C. , Zweegman,S. . Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2553.