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Biological activities of phenolic compounds and triterpenoids from the Galls of Terminalia chebula

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ชื่อเรื่อง : Biological activities of phenolic compounds and triterpenoids from the Galls of Terminalia chebula
นักวิจัย : Manosroi A. , Jantrawut P. , Ogihara E. , Yamamoto A. , Fukatsu M. , Yasukawa K. , Tokuda H. , Suzuki N. , Manosroi J. , Akihisa T.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : 16121872 , 10.1002/cbdv.201300149 , CBHIA , http://www.scopus.com/inward/record.url?eid=2-s2.0-84882309818&partnerID=40&md5=bc33cde62b52ee7485eb88f8d3b9e85b , http://cmuir.cmu.ac.th/handle/6653943832/4707
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Nine phenolic compounds, including two phenolic carboxylic acids, 1 and 2, seven hydrolyzable tannins, 3-9, eight triterpenoids, including four oleanane-type triterpene acids, 10-13, and four of their glucosides, 14-17, isolated from a MeOH extract of the gall of Terminalia chebula Retz. (myrobalan tree; Combretaceae), were evaluated for their inhibitory activities against melanogenesis in B16 melanoma cells induced by α-melanocyte-stimulating hormone (α-MSH), against the EpsteinBarr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells, and against TPA-induced inflammation in mice. Their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activities and cytotoxic activities against four human cancer cell lines were also evaluated. Compounds 6-9 and 12 exhibited potent inhibitory activities against melanogenesis (39.3-66.3% melanin content) with low toxicity to the cells (74.5-105.9% cell viability) at a concentration of 10 μM. Western-blot analysis revealed that isoterchebulin (8) reduced the protein levels of MITF (=microphtalmia-associated transcription factor), tyrosinase, and TRP-1 (=tyrosine-related protein 1), mostly in a concentration-dependent manner. Eight triterpenoids, 10-17, showed potent inhibitory effects on EBV-EA induction with the IC50 values in the range of 269-363 mol ratio/32 pmol TPA, while these compounds exhibited no DPPH scavenging activities (IC50>100 μM). On the other hand, the nine phenolic compounds, 1-9, exhibited potent radical-scavenging activities (IC50 1.4-10.9 μM) with weak inhibitory effects on EBV-EA induction (IC50 460-518 mol ratio/32 pmol TPA). The tannin 6 and seven triterpenoids, 10-16, have been shown to inhibit TPA-induced inflammation (1 μg/ear) in mice with the ID50 values in the range of 0.06-0.33 μmol/ear. Arjungenin (10) exhibited inhibitory effect on skin-tumor promotion in an in vivo two-stage mouse-skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator and with TPA as promoter. Compounds 1, 2, 4, 5, 7-9, 12, and 13, against HL60 cell line, compounds 1 and 4, against AZ521 cell line, and compounds 1, 11, and 12, against SK-BR-3 cell line, showed moderate cytotoxic activities (IC50 13.9-73.2 μM). Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich.

บรรณานุกรม :
Manosroi A. , Jantrawut P. , Ogihara E. , Yamamoto A. , Fukatsu M. , Yasukawa K. , Tokuda H. , Suzuki N. , Manosroi J. , Akihisa T. . (2556). Biological activities of phenolic compounds and triterpenoids from the Galls of Terminalia chebula.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Manosroi A. , Jantrawut P. , Ogihara E. , Yamamoto A. , Fukatsu M. , Yasukawa K. , Tokuda H. , Suzuki N. , Manosroi J. , Akihisa T. . 2556. "Biological activities of phenolic compounds and triterpenoids from the Galls of Terminalia chebula".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Manosroi A. , Jantrawut P. , Ogihara E. , Yamamoto A. , Fukatsu M. , Yasukawa K. , Tokuda H. , Suzuki N. , Manosroi J. , Akihisa T. . "Biological activities of phenolic compounds and triterpenoids from the Galls of Terminalia chebula."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2556. Print.
Manosroi A. , Jantrawut P. , Ogihara E. , Yamamoto A. , Fukatsu M. , Yasukawa K. , Tokuda H. , Suzuki N. , Manosroi J. , Akihisa T. . Biological activities of phenolic compounds and triterpenoids from the Galls of Terminalia chebula. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2556.