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Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892]

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ชื่อเรื่อง : Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892]
นักวิจัย : Teekachunhatean S. , Kunanusorn P. , Rojanasthien N. , Sananpanich K. , Pojchamarnwiputh S. , Lhieochaiphunt S. , Pruksakorn S.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2547
อ้างอิง : 14726882 , 10.1186/1472-6882-4-19 , 15588333 , BCAMC , http://www.scopus.com/inward/record.url?eid=2-s2.0-25444481576&partnerID=40&md5=7f67275d4194af6c3d7de6fc58e5971b , http://www.ncbi.nlm.nih.gov/pubmed/15588333 , http://cmuir.cmu.ac.th/handle/6653943832/3655
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Background: Duhuo Jisheng Wan (DJW) is perhaps the best known and most widely used Chinese herbal recipe for arthralgia, but the clinical study to verify its efficacy is lacking. The purpose of this study was to compare the efficacy of DJW versus diclofenac in symptomatic treatment of osteoarthritis (OA) of the knee. Methods: This study was a randomized, double-blind, double-dummy, controlled trial. The 200 patients suffering from OA of the knee, were randomized into the DJW and diclofenac group. The patients were evaluated after a run-in period of one week (week 0) and then weekly during 4 weeks of treatment. The clinical assessments included visual analog scale (VAS) score that assessed pain and stiffness, Lequesne's functional index, time for climbing up 10 steps, as well as physician's and patients' overall opinions on improvement. Results: Ninety four patients in each group completed the study. In the first few weeks of treatment, the mean changes in some variables (VAS, which assessed walking pain, standing pain and stiffness, as well as Lequesne's functional index) of the DJW group were significantly lower than those of the diclofenac group. Afterwards, these mean changes became no different throughout the study. Most of the physician's and patients' overall opinions on improvement at each time point did not significantly differ between the two groups. Approximately 30% of patients in both groups experienced mild adverse events. Conclusion: DJW demonstrates clinically comparable efficacy to diclofenac after 4 weeks of treatment. However, the slow onset of action as well as approximately equal rate of adverse events to diclofenac might limit its alternative role in treatment of OA of the knee. © 2004 Teekachunhatean et al; licensee BioMed Central Ltd.

บรรณานุกรม :
Teekachunhatean S. , Kunanusorn P. , Rojanasthien N. , Sananpanich K. , Pojchamarnwiputh S. , Lhieochaiphunt S. , Pruksakorn S. . (2547). Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892].
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Teekachunhatean S. , Kunanusorn P. , Rojanasthien N. , Sananpanich K. , Pojchamarnwiputh S. , Lhieochaiphunt S. , Pruksakorn S. . 2547. "Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892]".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Teekachunhatean S. , Kunanusorn P. , Rojanasthien N. , Sananpanich K. , Pojchamarnwiputh S. , Lhieochaiphunt S. , Pruksakorn S. . "Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892]."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2547. Print.
Teekachunhatean S. , Kunanusorn P. , Rojanasthien N. , Sananpanich K. , Pojchamarnwiputh S. , Lhieochaiphunt S. , Pruksakorn S. . Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: A randomized controlled trial [ISRCTN70292892]. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2547.