ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Tricyclic antidepressants for depressive disorders in children and adolescents: a meta-analysis of randomized-controlled trials

หน่วยงาน มหาวิทยาลัยเชียงใหม่

รายละเอียด

ชื่อเรื่อง : Tricyclic antidepressants for depressive disorders in children and adolescents: a meta-analysis of randomized-controlled trials
นักวิจัย : Maneeton N. , Srisurapanont M.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2543
อ้างอิง : 0125-2208 , 11215868 , http://www.ncbi.nlm.nih.gov/pubmed/3502482 , http://cmuir.cmu.ac.th/handle/6653943832/3291
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The tricyclic antidepressants (TCAs) are effective for the treatment of adult depression. However, their efficacy of these in the treatment of children and adolescents with depression is equivocal. Therefore, it is necessary to determine the efficacy and acceptability of TCAs in the treatment of depressive disorders in children and adolescents. The databases of MEDLINE (from 1966 to October 1999) and Controlled Clinical Trials Registered (from 1980 to October 1999) were searched for randomized-controlled trials relevant to the use of TCAs for treating depressed children and adolescents. The reviewers also examined the reference lists of identified papers and that of a previous meta-analysis. In each trial, both nonresponse rates and dropout rates were taken into account and extracted on an intention-to-treat basis. The nonresponse-rate and dropout-rate odd ratios (ORs) with 95 per cent confidence intervals (95% CIs) of each trial and the pooled non-response-rate and dropout-rate ORs (95% CIs) of all trials were computed. Nine trials included in this meta-analysis were 2 amitriptyline, 3 desipramine, 2 imipramine, and 2 nortriptyline studies. By using a fixed-effect model, the pooled nonresponse-rate OR (95% CI) and the pooled dropout rate OR (95% CI) of antidepressant-treated group were 0.92 (0.57 to 1.47) and 2.14 (1.12 to 4.09), respectively. In summary, the evidence so far does not support that TCAs are more effective or more acceptable than placebo in the treatment of depressive disorders in children and adolescents. However, the studies of selective serotonin reuptake inhibitors and newer antidepressants for the treatment of these disorders should be further investigated.

บรรณานุกรม :
Maneeton N. , Srisurapanont M. . (2543). Tricyclic antidepressants for depressive disorders in children and adolescents: a meta-analysis of randomized-controlled trials.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Maneeton N. , Srisurapanont M. . 2543. "Tricyclic antidepressants for depressive disorders in children and adolescents: a meta-analysis of randomized-controlled trials".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Maneeton N. , Srisurapanont M. . "Tricyclic antidepressants for depressive disorders in children and adolescents: a meta-analysis of randomized-controlled trials."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2543. Print.
Maneeton N. , Srisurapanont M. . Tricyclic antidepressants for depressive disorders in children and adolescents: a meta-analysis of randomized-controlled trials. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2543.