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Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients

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ชื่อเรื่อง : Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients
นักวิจัย : Chotayaporn T. , Kasitanon N. , Sukitawut W. , Louthrenoo W.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2554
อ้างอิง : 10761608 , 10.1097/RHU.0b013e318214bd18 , 21441821 , JCRHF , http://www.scopus.com/inward/record.url?eid=2-s2.0-79955072719&partnerID=40&md5=27b9deb50f1df93e0333943e68742998 , http://www.ncbi.nlm.nih.gov/pubmed/21441821 , http://cmuir.cmu.ac.th/handle/6653943832/2677
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Background: A simple, convenient, and accurate method for detecting urine protein excretion in lupus nephritis is crucial. Objectives: The objectives of the study were to determine the sensitivity and the specificity of the qualitative urine dipstick test value to detect 0.50 g or greater of the quantitative 24-hour urine protein (24-hUP) in lupus patients, to evaluate an overall agreement of the dipstick test results and the magnitude of 24-hUP, and to examine the correlation between the spot urine protein creatinine index (S-UPCI) and the 24-hour UPCI with that of the 24-hUp. Methods: A prospective study was conducted in 92 patients with lupus. All dipstick test values from 5 dipstick assays (Bayer, Roche, Meditest USA, Standard Diagnostics, and Arkray) and the S-UPCI were obtained within 6 hours of the 24-hUP collection. Of 149 urine samples, only 39% were collected properly and were used for analysis. Results: The sensitivity and specificity of a ≥2+ dipstick test result to detect 0.50 g or greater 24-hUP were 56-% to 80% and 67% to 92%, respectively. The agreement of the urine dipstick test values and the magnitude of 24-hUP was fair (κ = 0.23-0.32). The correlation between the S-UPCI and the 24-hUP was 0.83 (P < 0.0001), and that of the 24-hour UPCI and the 24-hUP was 1 (P < 0.0001). Using 24-hUP 2 g/d or less, the bias ±1.96 SD of the difference of S-UPCI and 24-hUP was 0.23 (SD, 0.96) g. Conclusions: A ≥2+ dipstick test is relatively sensitive to detect significant proteinuria, but it is poorly correlated with quantitative 24-hUP. The S-UPCI and the 24-hUP can be used interchangeably for follow-up in lupus nephritis patients with proteinuria of less than 2 g/d. Copyright © 2011 Lippincott Williams & Wilkins.

บรรณานุกรม :
Chotayaporn T. , Kasitanon N. , Sukitawut W. , Louthrenoo W. . (2554). Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Chotayaporn T. , Kasitanon N. , Sukitawut W. , Louthrenoo W. . 2554. "Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Chotayaporn T. , Kasitanon N. , Sukitawut W. , Louthrenoo W. . "Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2554. Print.
Chotayaporn T. , Kasitanon N. , Sukitawut W. , Louthrenoo W. . Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2554.