ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

FOLFIRI chemotherapy for metastatic colorectal cancer patients

หน่วยงาน มหาวิทยาลัยเชียงใหม่

รายละเอียด

ชื่อเรื่อง : FOLFIRI chemotherapy for metastatic colorectal cancer patients
นักวิจัย : Kamnerdsupaphon P. , Lorvidhaya V. , Chitapanarux I. , Tonusin A. , Sukthomya V.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2550
อ้างอิง : 01252208 , 18041432 , JMTHB , http://www.scopus.com/inward/record.url?eid=2-s2.0-35848959497&partnerID=40&md5=c00a2c1fe2bf594897777d95f4e77f39 , http://www.ncbi.nlm.nih.gov/pubmed/18041432 , http://cmuir.cmu.ac.th/handle/6653943832/2127
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Objectives: 1) To confirm the efficacy of irinotecan plus folinic acid/continuous 5-fluorouracil as bimonthly FOLFIRI regimen in metastatic colorectal cancer patients. Efficacy evaluations will include response rate, duration of response, and survival. 2) To evaluate safety profiles on patients receiving this combination. Material and Method: Nineteen patients with metastatic colorectal cancer received 180mg/m2 intravenous (iv) day 1 of irinotecan, 200 mg/m2 iv of folinic acid, 400 mg/m2 iv bolus days 1 to 2, 5-fluorouracil (5-FU), and 600 mg/m2 iv 5-FU infusion over 22 hours, days 1 to 2. Treatment was repeated every two weeks and one cycle contained three fortnightly administrations. Sites of disease were liver in nine patients, lungs in three patients, bowels in four patients, lymph nodes in three patients, and peritoneum in two patients. Two patients had >1 metastatic site. Previous treatments included adjuvant chemotherapy in seven cases and front-line chemotherapy for advanced disease in one case. Results: A median of six treatment cycles was completed (range, 2-13 cycles). All patients were assessable for toxicity and 16 patients were evaluable for treatment response. The non-hematological toxicity was mild. Most had grade 1 or 2. Only one patient experienced grade 3 fatigue and anorexia, and discontinued chemotherapy after the second cycle. There were no cases with grade 4 toxicity. Fourteen patients had at least grade 2 alopecia. The most common hematological toxicity was neutropenia. Grade 3 and 4 neutropenia were observed in three and two patients, respectively. There was no case of febrile neutropenia. Based on intention to treat analysis, there were no complete responses (CR), five (26.3%) partial response (PR), and 11 (57.9%) stable disease. With the median follow-up of 6.6 months, the median time to disease progression was 4.7 months and the median survival time was 10.6 months. Conclusion: Bimonthly irinotecan in combination with folinic acid and 5-fluorouracil was active with acceptable toxicities and a prolonged survival time in pretreated colorectal cancer. Additional trials to define the optimal dose and schedule of treatment are justified.

บรรณานุกรม :
Kamnerdsupaphon P. , Lorvidhaya V. , Chitapanarux I. , Tonusin A. , Sukthomya V. . (2550). FOLFIRI chemotherapy for metastatic colorectal cancer patients.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Kamnerdsupaphon P. , Lorvidhaya V. , Chitapanarux I. , Tonusin A. , Sukthomya V. . 2550. "FOLFIRI chemotherapy for metastatic colorectal cancer patients".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Kamnerdsupaphon P. , Lorvidhaya V. , Chitapanarux I. , Tonusin A. , Sukthomya V. . "FOLFIRI chemotherapy for metastatic colorectal cancer patients."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2550. Print.
Kamnerdsupaphon P. , Lorvidhaya V. , Chitapanarux I. , Tonusin A. , Sukthomya V. . FOLFIRI chemotherapy for metastatic colorectal cancer patients. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2550.