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Preoperative capecitabine with pelvic radiotherapy for locally advanced rectal cancer (phase I trial)

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ชื่อเรื่อง : Preoperative capecitabine with pelvic radiotherapy for locally advanced rectal cancer (phase I trial)
นักวิจัย : Veerasarn V. , Phromratanapongse P. , Lorvidhaya V. , Lertsanguansinchai P. , Lertbutsayanukul C. , Panichevaluk A. , Boonnuch W. , Chinswangwatanakul V. , Lohsiriwat D. , Rojanasakul A. , Thavichaigarn P. , Jivapaisarnpong P.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2549
อ้างอิง : 01252208 , 17205868 , JMTHB , http://www.scopus.com/inward/record.url?eid=2-s2.0-33845495420&partnerID=40&md5=31aee1aa06e324d9dc4b8648a1d6bbd4 , http://cmuir.cmu.ac.th/handle/6653943832/2017
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Objective: Phase I multicenter study defined the maximal tolerated dose (MTD), dose-limiting toxicity (DLT) and safety profile of capecitabine in combination with preoperative radiation for patients with locally advanced rectal cancer (LARC). Material and Method: Patients were treated with oral capecitabine (700, 800, 900, 1000, 1100 and 1200 mg/ m2 twice daily continuously) plus preoperative whole pelvic irradiation (45-46 Gy in 23-25 fractions over 5-6 weeks). Surgery was performed at the median of 42 days after chemoradiation treatment. Results: Twenty-seven patients were in this trial. Eighteen patients (3 per dose level) had received capecitabine from 700 mg/m2 twice daily to the highest dose level of 1200 mg/m2 twice daily. There were no grade 3/4 DLTs during dose escalation, a further nine patients were included at the highest capecitabine dose. Two of the twelve patients (16%) receiving capecitabine 1200 mg/m2 twice daily developed grade 3 diarrhea and discontinued treatment. There were no other grade 3/4 adverse events. After capecitabine chemoradiation, 24 of 27 patients (89%) received definite surgery. Primary and lymph node down staging occurred in ten patients (42%). Sphincter-sparing surgery was performed in seven patients (26%) and abdominal-perineal resection was performed in 17 patients (63%). Conclusion: Preoperative capecitabine chemoradiation based on continuous daily capecitabine is very well tolerated in patients with LARC. The authors did not reach the MTD in the present study.

บรรณานุกรม :
Veerasarn V. , Phromratanapongse P. , Lorvidhaya V. , Lertsanguansinchai P. , Lertbutsayanukul C. , Panichevaluk A. , Boonnuch W. , Chinswangwatanakul V. , Lohsiriwat D. , Rojanasakul A. , Thavichaigarn P. , Jivapaisarnpong P. . (2549). Preoperative capecitabine with pelvic radiotherapy for locally advanced rectal cancer (phase I trial).
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Veerasarn V. , Phromratanapongse P. , Lorvidhaya V. , Lertsanguansinchai P. , Lertbutsayanukul C. , Panichevaluk A. , Boonnuch W. , Chinswangwatanakul V. , Lohsiriwat D. , Rojanasakul A. , Thavichaigarn P. , Jivapaisarnpong P. . 2549. "Preoperative capecitabine with pelvic radiotherapy for locally advanced rectal cancer (phase I trial)".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Veerasarn V. , Phromratanapongse P. , Lorvidhaya V. , Lertsanguansinchai P. , Lertbutsayanukul C. , Panichevaluk A. , Boonnuch W. , Chinswangwatanakul V. , Lohsiriwat D. , Rojanasakul A. , Thavichaigarn P. , Jivapaisarnpong P. . "Preoperative capecitabine with pelvic radiotherapy for locally advanced rectal cancer (phase I trial)."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2549. Print.
Veerasarn V. , Phromratanapongse P. , Lorvidhaya V. , Lertsanguansinchai P. , Lertbutsayanukul C. , Panichevaluk A. , Boonnuch W. , Chinswangwatanakul V. , Lohsiriwat D. , Rojanasakul A. , Thavichaigarn P. , Jivapaisarnpong P. . Preoperative capecitabine with pelvic radiotherapy for locally advanced rectal cancer (phase I trial). เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2549.