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Phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer

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ชื่อเรื่อง : Phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer
นักวิจัย : Ratanatharathorn V. , Lorvidhaya V. , Maoleekoonpairoj S. , Phromratanapongse P. , Sirilerttrakul S. , Kraipiboon P. , Cheirsilpa A. , Tangkaratt S. , Srimuninnimit V. , Pattaranutaporn P.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2544
อ้างอิง : 01695002 , 10.1016/S0169-5002(00)00171-9 , 11165405 , LUCAE , http://www.scopus.com/inward/record.url?eid=2-s2.0-0035139474&partnerID=40&md5=c3ed54527fb5051eb86c5935ab6f463f , http://cmuir.cmu.ac.th/handle/6653943832/2006
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

We conducted a phase II trial to investigate the efficacy of concurrent chemoradiation in patients with stage III non-small-cell lung cancer (NSCLC). Thirty patients with inoperable NSCLC were enrolled onto a multicenter phase II trial of concurrent chemoradiation therapy. Patients received six weekly cycles of paclitaxel 45 mg/m2 over 1 h; carboplatin at (area under the curve) AUC 2; and radiation therapy of 60 Gy. Radiation was administered to the primary tumor and regional lymph nodes (40 Gy over 4 weeks) followed by a boost to the primary tumor (20 Gy in 2 weeks). After the initial phase of concurrent chemoradiation, patients received an additional four cycles of paclitaxel 175 mg/m2 over 3 h and carboplatin at AUC 6 every 3 weeks. The overall objective response rate of 30 assessable patients was 76.7%. At the median follow-up time of 13.1 months, the median survival time was 14.5 months (95% CI, 10.59-18.48). The median progression-free survival was 10.5 months (95% CI, 7.72-13.28). The major toxicity was hematologic. The incidence of grade 3 esophagitis was 10%. In conclusion, this chemoradiation regimen is well tolerated and shows significant clinical results for locally advanced NSCLC. Locoregional failure rate remains an important issue with this newer chemotherapeutic regimen. A novel chemotherapy and radiation therapy is clearly needed. Copyright © 2001 Elsevier Science Ireland Ltd.

บรรณานุกรม :
Ratanatharathorn V. , Lorvidhaya V. , Maoleekoonpairoj S. , Phromratanapongse P. , Sirilerttrakul S. , Kraipiboon P. , Cheirsilpa A. , Tangkaratt S. , Srimuninnimit V. , Pattaranutaporn P. . (2544). Phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Ratanatharathorn V. , Lorvidhaya V. , Maoleekoonpairoj S. , Phromratanapongse P. , Sirilerttrakul S. , Kraipiboon P. , Cheirsilpa A. , Tangkaratt S. , Srimuninnimit V. , Pattaranutaporn P. . 2544. "Phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Ratanatharathorn V. , Lorvidhaya V. , Maoleekoonpairoj S. , Phromratanapongse P. , Sirilerttrakul S. , Kraipiboon P. , Cheirsilpa A. , Tangkaratt S. , Srimuninnimit V. , Pattaranutaporn P. . "Phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2544. Print.
Ratanatharathorn V. , Lorvidhaya V. , Maoleekoonpairoj S. , Phromratanapongse P. , Sirilerttrakul S. , Kraipiboon P. , Cheirsilpa A. , Tangkaratt S. , Srimuninnimit V. , Pattaranutaporn P. . Phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2544.