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Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine

หน่วยงาน มหาวิทยาลัยเชียงใหม่

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ชื่อเรื่อง : Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine
นักวิจัย : Pornprasert S. , Mary J.-Y. , Faye A. , Leechanachai P. , Limtrakul A. , Rugpao S. , Sirivatanapa P. , Gomuthbutra V. , Matanasaravoot W. , Le Coeur S. , Lallemant M. , Barre-Sinoussi F. , Menu E. , Ngo-Giang-Huong N. , Ayouba A. , Chailert S. , Chaouat G. , Derrien M. , Dolcini G. , Eteki N. , Kfutwah A.J. , Kouo O. , Lemen B. , Maldonado-Estrada J. , Nerrienet E. , Njinku B. , Scarlatti G. , Tejiokem M. , Tene G.
คำค้น : -
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2552
อ้างอิง : 1570162X , 10.2174/157016209787581472 , 19275589 , CHRUB , http://www.scopus.com/inward/record.url?eid=2-s2.0-64749097199&partnerID=40&md5=20c9efc3c607ff9233b90db77b0c4d47 , http://www.ncbi.nlm.nih.gov/pubmed/19275589 , http://cmuir.cmu.ac.th/handle/6653943832/776
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Placental cytokine balance may be critical for the control of mother-to-child transmission (MTCT) of HIV. We assessed whether the type and duration of antiretrovirals used for prevention of HIV-1-MTCT modified the inflammatory cytokine profile. We investigated the levels of cytokine expression in the placentas of 61 HIV-1-infected women who received zidovudine (ZDV) plus single dose nevirapine (SD-NVP) or ZDV only for prevention of MTCT. Placentas of 38 HIV-1-uninfected women were included as controls. All placentas were obtained after vaginal delivery. Levels of mRNA and cytokine expression were quantified using real-time PCR and ELISA, respectively, in placental explants and 24-hour culture supernatants and analyzed in relation to the women's characteristics and the type and duration of antiretroviral prophylaxis. HIV-1-infected and uninfected women did not show any differences in the expression of placental cytokine secretion except for a trend toward lower TNF-10 mRNA levels in HIV-1-infected women. Within the HIV-1-infected group, women who were exposed to a long duration of ZDV (>72 days) or received SD-NVP less than 5h prior to delivery, more frequently expressed detectable levels of IL-10 in their placentas (32% versus 7% (p = 0.01) and 32% versus 5% (p = 0.02), respectively). No infant was found to be HIV-1-infected. Our results showed a normalization of the placental cytokine balance in HIV-1-infected women receiving antiretroviral prophylaxis. Furthermore, the type and duration of antiretroviral prophylaxis have an impact on the placental anti-inflammatory IL-10 expression level, which may contribute to controlling HIV replication at the placental level, thus reducing MTCT of HIV-1. © 2009 Bentham Science Publishers Ltd.

บรรณานุกรม :
Pornprasert S. , Mary J.-Y. , Faye A. , Leechanachai P. , Limtrakul A. , Rugpao S. , Sirivatanapa P. , Gomuthbutra V. , Matanasaravoot W. , Le Coeur S. , Lallemant M. , Barre-Sinoussi F. , Menu E. , Ngo-Giang-Huong N. , Ayouba A. , Chailert S. , Chaouat G. , Derrien M. , Dolcini G. , Eteki N. , Kfutwah A.J. , Kouo O. , Lemen B. , Maldonado-Estrada J. , Nerrienet E. , Njinku B. , Scarlatti G. , Tejiokem M. , Tene G. . (2552). Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Pornprasert S. , Mary J.-Y. , Faye A. , Leechanachai P. , Limtrakul A. , Rugpao S. , Sirivatanapa P. , Gomuthbutra V. , Matanasaravoot W. , Le Coeur S. , Lallemant M. , Barre-Sinoussi F. , Menu E. , Ngo-Giang-Huong N. , Ayouba A. , Chailert S. , Chaouat G. , Derrien M. , Dolcini G. , Eteki N. , Kfutwah A.J. , Kouo O. , Lemen B. , Maldonado-Estrada J. , Nerrienet E. , Njinku B. , Scarlatti G. , Tejiokem M. , Tene G. . 2552. "Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Pornprasert S. , Mary J.-Y. , Faye A. , Leechanachai P. , Limtrakul A. , Rugpao S. , Sirivatanapa P. , Gomuthbutra V. , Matanasaravoot W. , Le Coeur S. , Lallemant M. , Barre-Sinoussi F. , Menu E. , Ngo-Giang-Huong N. , Ayouba A. , Chailert S. , Chaouat G. , Derrien M. , Dolcini G. , Eteki N. , Kfutwah A.J. , Kouo O. , Lemen B. , Maldonado-Estrada J. , Nerrienet E. , Njinku B. , Scarlatti G. , Tejiokem M. , Tene G. . "Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2552. Print.
Pornprasert S. , Mary J.-Y. , Faye A. , Leechanachai P. , Limtrakul A. , Rugpao S. , Sirivatanapa P. , Gomuthbutra V. , Matanasaravoot W. , Le Coeur S. , Lallemant M. , Barre-Sinoussi F. , Menu E. , Ngo-Giang-Huong N. , Ayouba A. , Chailert S. , Chaouat G. , Derrien M. , Dolcini G. , Eteki N. , Kfutwah A.J. , Kouo O. , Lemen B. , Maldonado-Estrada J. , Nerrienet E. , Njinku B. , Scarlatti G. , Tejiokem M. , Tene G. . Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2552.